Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep–wake Disturbances in AD Mice

Alzheimer’s disease (AD) increases the risk for seizures and sleep disorders. We show here that germline deletion of β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) in neurons, but not in astrocytes, increased epileptiform activity. However, Bace1 deletion at adult ages did not alte...

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Detalles Bibliográficos
Autores principales: Yao, Annie Y., Halloran, Patrick J., Ge, Yingying, Singh, Neeraj, Zhou, John, Galske, James, He, Wanxia, Yan, Riqiang, Hu, Xiangyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476643/
https://www.ncbi.nlm.nih.gov/pubmed/37536983
http://dx.doi.org/10.1523/JNEUROSCI.2124-22.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476643/
https://www.ncbi.nlm.nih.gov/pubmed/37536983
http://dx.doi.org/10.1523/JNEUROSCI.2124-22.2023

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