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Sputum Neurturin Levels in Adult Asthmatic Subjects

BACKGROUND: Neurturin (NRTN) is a neurotrophic factor that was originally identified in the development and maintenance of neural cells. Recent studies involving NRTN knockout mice have reported its anti-inflammatory effects in allergic airway conditions. However, the role of NRTN in human asthma ha...

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Autores principales: Sato, Suguru, Suzuki, Yasuhito, Kikuchi, Masami, Rikimaru, Mami, Saito, Junpei, Shibata, Yoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476664/
https://www.ncbi.nlm.nih.gov/pubmed/37671183
http://dx.doi.org/10.2147/JAA.S421742
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author Sato, Suguru
Suzuki, Yasuhito
Kikuchi, Masami
Rikimaru, Mami
Saito, Junpei
Shibata, Yoko
author_facet Sato, Suguru
Suzuki, Yasuhito
Kikuchi, Masami
Rikimaru, Mami
Saito, Junpei
Shibata, Yoko
author_sort Sato, Suguru
collection PubMed
description BACKGROUND: Neurturin (NRTN) is a neurotrophic factor that was originally identified in the development and maintenance of neural cells. Recent studies involving NRTN knockout mice have reported its anti-inflammatory effects in allergic airway conditions. However, the role of NRTN in human asthma has not yet been identified. OBJECTIVE: The purposes of the present study were to confirm the presence of NRTN in the airways and to investigate the clinical and pathogenetic roles of NRTN in asthma. METHODS: The NRTN levels in the induced sputum were measured by enzyme-linked immunosorbent assay (ELISA). Relationships between NRTN and clinical characteristics, asthma control status, and airway inflammation were assessed. RESULTS: Sixty-four asthmatic subjects were enrolled in the study. All asthmatic subjects had detectable sputum NRTN levels, with a mean (SD) level of 2.03 (1.29) ng/mL. The sputum NRTN levels had significant positive correlations with sputum eosinophil and exhaled nitric oxide levels and were significantly higher in the atopic subjects than in the non-atopic subjects. No significant difference in sputum NRTN levels were observed for asthma control status and asthma exacerbation. In sputum inflammatory analyses, sputum NRTN level was positively correlated with interleukin (IL)-5 and IL-13 levels, and negatively correlated with matrix metalloproteinase (MMP)-9 level. CONCLUSION: It is plausible that sputum NRTN could serve as a new marker for Type 2 airway inflammation, implicating its role in the process of airway remodeling in asthma. Future studies should investigate the clinical relevance of sputum NRTN level in prospective analyses.
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spelling pubmed-104766642023-09-05 Sputum Neurturin Levels in Adult Asthmatic Subjects Sato, Suguru Suzuki, Yasuhito Kikuchi, Masami Rikimaru, Mami Saito, Junpei Shibata, Yoko J Asthma Allergy Original Research BACKGROUND: Neurturin (NRTN) is a neurotrophic factor that was originally identified in the development and maintenance of neural cells. Recent studies involving NRTN knockout mice have reported its anti-inflammatory effects in allergic airway conditions. However, the role of NRTN in human asthma has not yet been identified. OBJECTIVE: The purposes of the present study were to confirm the presence of NRTN in the airways and to investigate the clinical and pathogenetic roles of NRTN in asthma. METHODS: The NRTN levels in the induced sputum were measured by enzyme-linked immunosorbent assay (ELISA). Relationships between NRTN and clinical characteristics, asthma control status, and airway inflammation were assessed. RESULTS: Sixty-four asthmatic subjects were enrolled in the study. All asthmatic subjects had detectable sputum NRTN levels, with a mean (SD) level of 2.03 (1.29) ng/mL. The sputum NRTN levels had significant positive correlations with sputum eosinophil and exhaled nitric oxide levels and were significantly higher in the atopic subjects than in the non-atopic subjects. No significant difference in sputum NRTN levels were observed for asthma control status and asthma exacerbation. In sputum inflammatory analyses, sputum NRTN level was positively correlated with interleukin (IL)-5 and IL-13 levels, and negatively correlated with matrix metalloproteinase (MMP)-9 level. CONCLUSION: It is plausible that sputum NRTN could serve as a new marker for Type 2 airway inflammation, implicating its role in the process of airway remodeling in asthma. Future studies should investigate the clinical relevance of sputum NRTN level in prospective analyses. Dove 2023-08-31 /pmc/articles/PMC10476664/ /pubmed/37671183 http://dx.doi.org/10.2147/JAA.S421742 Text en © 2023 Sato et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Sato, Suguru
Suzuki, Yasuhito
Kikuchi, Masami
Rikimaru, Mami
Saito, Junpei
Shibata, Yoko
Sputum Neurturin Levels in Adult Asthmatic Subjects
title Sputum Neurturin Levels in Adult Asthmatic Subjects
title_full Sputum Neurturin Levels in Adult Asthmatic Subjects
title_fullStr Sputum Neurturin Levels in Adult Asthmatic Subjects
title_full_unstemmed Sputum Neurturin Levels in Adult Asthmatic Subjects
title_short Sputum Neurturin Levels in Adult Asthmatic Subjects
title_sort sputum neurturin levels in adult asthmatic subjects
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476664/
https://www.ncbi.nlm.nih.gov/pubmed/37671183
http://dx.doi.org/10.2147/JAA.S421742
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