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Comprehensive pan-cancer analysis of expression profiles and prognostic significance for NUMB and NUMBL in human tumors

NUMB has been initially identified as a critical cell fate determinant that modulates cell differentiation via asymmetrical partitioning during mitosis, including tumor cells. However, it remains absent that a systematic assessment of the mechanisms underlying NUMB and its homologous protein NUMBLIK...

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Autores principales: Zhang, Yue, Yang, Hongxia, Liu, Weizhe, Song, Qiuhang, Li, Yunfeng, Zhang, Juanjuan, Zhou, Dingyan, Li, Aiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476719/
https://www.ncbi.nlm.nih.gov/pubmed/37657045
http://dx.doi.org/10.1097/MD.0000000000034717
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author Zhang, Yue
Yang, Hongxia
Liu, Weizhe
Song, Qiuhang
Li, Yunfeng
Zhang, Juanjuan
Zhou, Dingyan
Li, Aiying
author_facet Zhang, Yue
Yang, Hongxia
Liu, Weizhe
Song, Qiuhang
Li, Yunfeng
Zhang, Juanjuan
Zhou, Dingyan
Li, Aiying
author_sort Zhang, Yue
collection PubMed
description NUMB has been initially identified as a critical cell fate determinant that modulates cell differentiation via asymmetrical partitioning during mitosis, including tumor cells. However, it remains absent that a systematic assessment of the mechanisms underlying NUMB and its homologous protein NUMBLIKE (NUMBL) involvement in cancer. This study aimed to investigate the prognostic significance for NUMB and NUMBL in pan-cancer. In this study, using the online databases TIMER2.0, gene expression profiling interactive analysis, cBioPortal, the University of ALabama at Birmingham CANcer data analysis Portal, SearchTool for the Retrieval of Interacting Genes/Proteins, and R software, we focused on the relevance between NUMB/NUMBL and oncogenesis, progression, mutation, phosphorylation, function and prognosis. This study demonstrated that abnormal expression of NUMB and NUMBL were found to be significantly associated with clinicopathologic stages and the prognosis of survival. Besides, genetic alternations of NUMB and NUMBL focused on uterine corpus endometrial carcinoma, and higher genetic mutations of NUMBL were correlated with more prolonged overall survival and disease-free survival in different cancers. Moreover, S438 locus of NUMB peptide fragment was frequently phosphorylated in 4 cancer types and relevant to its phosphorylation sites. Furthermore, endocytosis processing and neurogenesis regulation were involved in the functional mechanisms of NUMB and NUMBL separately. Additionally, the pathway enrichment suggested that NUMB was implicated in Hippo, Neurotrophin, Thyroid hormone, and FoxO pathways, while MAPK, Hippo, Rap1, mTOR, and Notch pathways were related to the functions of NUMBL. This study highlights the predictive roles of NUMB and NUMBL in pan-cancer, suggesting NUMB and NUMBL might be served as potential biomarkers for diagnosis and prognosis in various malignant tumors.
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spelling pubmed-104767192023-09-05 Comprehensive pan-cancer analysis of expression profiles and prognostic significance for NUMB and NUMBL in human tumors Zhang, Yue Yang, Hongxia Liu, Weizhe Song, Qiuhang Li, Yunfeng Zhang, Juanjuan Zhou, Dingyan Li, Aiying Medicine (Baltimore) 5700 NUMB has been initially identified as a critical cell fate determinant that modulates cell differentiation via asymmetrical partitioning during mitosis, including tumor cells. However, it remains absent that a systematic assessment of the mechanisms underlying NUMB and its homologous protein NUMBLIKE (NUMBL) involvement in cancer. This study aimed to investigate the prognostic significance for NUMB and NUMBL in pan-cancer. In this study, using the online databases TIMER2.0, gene expression profiling interactive analysis, cBioPortal, the University of ALabama at Birmingham CANcer data analysis Portal, SearchTool for the Retrieval of Interacting Genes/Proteins, and R software, we focused on the relevance between NUMB/NUMBL and oncogenesis, progression, mutation, phosphorylation, function and prognosis. This study demonstrated that abnormal expression of NUMB and NUMBL were found to be significantly associated with clinicopathologic stages and the prognosis of survival. Besides, genetic alternations of NUMB and NUMBL focused on uterine corpus endometrial carcinoma, and higher genetic mutations of NUMBL were correlated with more prolonged overall survival and disease-free survival in different cancers. Moreover, S438 locus of NUMB peptide fragment was frequently phosphorylated in 4 cancer types and relevant to its phosphorylation sites. Furthermore, endocytosis processing and neurogenesis regulation were involved in the functional mechanisms of NUMB and NUMBL separately. Additionally, the pathway enrichment suggested that NUMB was implicated in Hippo, Neurotrophin, Thyroid hormone, and FoxO pathways, while MAPK, Hippo, Rap1, mTOR, and Notch pathways were related to the functions of NUMBL. This study highlights the predictive roles of NUMB and NUMBL in pan-cancer, suggesting NUMB and NUMBL might be served as potential biomarkers for diagnosis and prognosis in various malignant tumors. Lippincott Williams & Wilkins 2023-09-01 /pmc/articles/PMC10476719/ /pubmed/37657045 http://dx.doi.org/10.1097/MD.0000000000034717 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5700
Zhang, Yue
Yang, Hongxia
Liu, Weizhe
Song, Qiuhang
Li, Yunfeng
Zhang, Juanjuan
Zhou, Dingyan
Li, Aiying
Comprehensive pan-cancer analysis of expression profiles and prognostic significance for NUMB and NUMBL in human tumors
title Comprehensive pan-cancer analysis of expression profiles and prognostic significance for NUMB and NUMBL in human tumors
title_full Comprehensive pan-cancer analysis of expression profiles and prognostic significance for NUMB and NUMBL in human tumors
title_fullStr Comprehensive pan-cancer analysis of expression profiles and prognostic significance for NUMB and NUMBL in human tumors
title_full_unstemmed Comprehensive pan-cancer analysis of expression profiles and prognostic significance for NUMB and NUMBL in human tumors
title_short Comprehensive pan-cancer analysis of expression profiles and prognostic significance for NUMB and NUMBL in human tumors
title_sort comprehensive pan-cancer analysis of expression profiles and prognostic significance for numb and numbl in human tumors
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476719/
https://www.ncbi.nlm.nih.gov/pubmed/37657045
http://dx.doi.org/10.1097/MD.0000000000034717
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