Gastric Cancer Screening in First-Degree Relatives: A Pilot Study in a Diverse Integrated Healthcare System

INTRODUCTION: Family history of gastric cancer has been shown as an independent risk factor of gastric cancer development and is associated with increased risk of progression to gastric cancer among patients with gastric intestinal metaplasia (GIM). METHODS: Between 2017 and 2020, we conducted a pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Dong, Elizabeth Y., Giap, Andrew Q., Lustigova, Eva, Wu, Bechien U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476735/
https://www.ncbi.nlm.nih.gov/pubmed/36113027
http://dx.doi.org/10.14309/ctg.0000000000000531
_version_ 1785100995803480064
author Dong, Elizabeth Y.
Giap, Andrew Q.
Lustigova, Eva
Wu, Bechien U.
author_facet Dong, Elizabeth Y.
Giap, Andrew Q.
Lustigova, Eva
Wu, Bechien U.
author_sort Dong, Elizabeth Y.
collection PubMed
description INTRODUCTION: Family history of gastric cancer has been shown as an independent risk factor of gastric cancer development and is associated with increased risk of progression to gastric cancer among patients with gastric intestinal metaplasia (GIM). METHODS: Between 2017 and 2020, we conducted a prospective pilot screening program of patients with a confirmed first-degree relative with gastric cancer to evaluate the feasibility of screening and prevalence of precursor lesions (e.g., GIM or dysplasia) on biopsy. RESULTS: A total of 61 patients completed screening by upper endoscopy with a mapping biopsy protocol: 27 (44%) were found to have GIM and 4 (7%) were found with low-grade dysplasia. DISCUSSION: Our pilot screening program identified a high prevalence of precursor lesions for gastric cancer among asymptomatic patients with a first-degree relative with gastric cancer. Careful endoscopic inspection and standardized biopsy protocols may aid in prompt identification of these precursor lesions in those at risk of gastric cancer.
format Online
Article
Text
id pubmed-10476735
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Wolters Kluwer
record_format MEDLINE/PubMed
spelling pubmed-104767352023-09-05 Gastric Cancer Screening in First-Degree Relatives: A Pilot Study in a Diverse Integrated Healthcare System Dong, Elizabeth Y. Giap, Andrew Q. Lustigova, Eva Wu, Bechien U. Clin Transl Gastroenterol Brief Report INTRODUCTION: Family history of gastric cancer has been shown as an independent risk factor of gastric cancer development and is associated with increased risk of progression to gastric cancer among patients with gastric intestinal metaplasia (GIM). METHODS: Between 2017 and 2020, we conducted a prospective pilot screening program of patients with a confirmed first-degree relative with gastric cancer to evaluate the feasibility of screening and prevalence of precursor lesions (e.g., GIM or dysplasia) on biopsy. RESULTS: A total of 61 patients completed screening by upper endoscopy with a mapping biopsy protocol: 27 (44%) were found to have GIM and 4 (7%) were found with low-grade dysplasia. DISCUSSION: Our pilot screening program identified a high prevalence of precursor lesions for gastric cancer among asymptomatic patients with a first-degree relative with gastric cancer. Careful endoscopic inspection and standardized biopsy protocols may aid in prompt identification of these precursor lesions in those at risk of gastric cancer. Wolters Kluwer 2022-09-16 /pmc/articles/PMC10476735/ /pubmed/36113027 http://dx.doi.org/10.14309/ctg.0000000000000531 Text en © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Brief Report
Dong, Elizabeth Y.
Giap, Andrew Q.
Lustigova, Eva
Wu, Bechien U.
Gastric Cancer Screening in First-Degree Relatives: A Pilot Study in a Diverse Integrated Healthcare System
title Gastric Cancer Screening in First-Degree Relatives: A Pilot Study in a Diverse Integrated Healthcare System
title_full Gastric Cancer Screening in First-Degree Relatives: A Pilot Study in a Diverse Integrated Healthcare System
title_fullStr Gastric Cancer Screening in First-Degree Relatives: A Pilot Study in a Diverse Integrated Healthcare System
title_full_unstemmed Gastric Cancer Screening in First-Degree Relatives: A Pilot Study in a Diverse Integrated Healthcare System
title_short Gastric Cancer Screening in First-Degree Relatives: A Pilot Study in a Diverse Integrated Healthcare System
title_sort gastric cancer screening in first-degree relatives: a pilot study in a diverse integrated healthcare system
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476735/
https://www.ncbi.nlm.nih.gov/pubmed/36113027
http://dx.doi.org/10.14309/ctg.0000000000000531
work_keys_str_mv AT dongelizabethy gastriccancerscreeninginfirstdegreerelativesapilotstudyinadiverseintegratedhealthcaresystem
AT giapandrewq gastriccancerscreeninginfirstdegreerelativesapilotstudyinadiverseintegratedhealthcaresystem
AT lustigovaeva gastriccancerscreeninginfirstdegreerelativesapilotstudyinadiverseintegratedhealthcaresystem
AT wubechienu gastriccancerscreeninginfirstdegreerelativesapilotstudyinadiverseintegratedhealthcaresystem

Ejemplares similares