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Association between chromosome abnormities and prenatal diagnosis indicators screening in the second trimester of pregnancy

This study aimed to explore the prenatal indicators in the second trimester of pregnancy and their association with chromosome abnormities (CA) to guide decisions toward invasive diagnostic procedures. Pregnant women who underwent prenatal screening and underwent amniocentesis in the second trimeste...

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Autores principales: Pan, Ci, Li, Zilong, Cheng, Guomei, Luo, Xiaohua, Nie, Fufang, Gao, Jing, Yang, Peifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476756/
https://www.ncbi.nlm.nih.gov/pubmed/37657051
http://dx.doi.org/10.1097/MD.0000000000034762
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author Pan, Ci
Li, Zilong
Cheng, Guomei
Luo, Xiaohua
Nie, Fufang
Gao, Jing
Yang, Peifeng
author_facet Pan, Ci
Li, Zilong
Cheng, Guomei
Luo, Xiaohua
Nie, Fufang
Gao, Jing
Yang, Peifeng
author_sort Pan, Ci
collection PubMed
description This study aimed to explore the prenatal indicators in the second trimester of pregnancy and their association with chromosome abnormities (CA) to guide decisions toward invasive diagnostic procedures. Pregnant women who underwent prenatal screening and underwent amniocentesis in the second trimester in our Hospital between June 2017 and February 2019 were included in this retrospective cohort study. The reason for amniocentesis in prenatal screening and diagnoses was extracted from the charts. Finally, 3449 pregnant women were included. Of them, 181 were with CA confirmed by amniocentesis (i.e., the CA group), while 3268 were without CA (i.e., the non-CA group). Compared with the women in the non-CA group, those in the CA group were more likely to be older (30 [27,32] vs 29 [26,31], P < .001), had higher gestational weeks (20 [19,23] vs 19 [18,23], P = .008), an increased risk of advanced maternal age (AMA) (9.4% vs 2.2%, P < .001), had an increased risk of NIPT (IRN) (5.1% vs 1.9%, P < .001), had higher rates of a parental chromosome abnormality (PCA) (1.8% vs 0.9%, P = .002), and had increased risk of trisomy 21 (IRT21) (63.0% vs 45.3%, P < .001). AMA (OR = 4.22, 95% CI: 2.35–7.58, P < .001; AUC = 0.536), IRN (OR = 10.62, 95% CI: 6.66–16.94, P < .001; AUC = 0.589), PCA (OR = 4.77, 95% CI: 2.01–11.32, P < .001; AUC = 0.584), and IRT21 (OR = 0.67, 95% CI: 0.47–0.89, P = .008; AUC = 0.515) were independently associated with CA. AMA, IRN, IRT21, and PCA during the second trimester were independently associated with CA, but their predictive values for CA were relatively low. Combining those indicators may improve the predictive value.
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spelling pubmed-104767562023-09-05 Association between chromosome abnormities and prenatal diagnosis indicators screening in the second trimester of pregnancy Pan, Ci Li, Zilong Cheng, Guomei Luo, Xiaohua Nie, Fufang Gao, Jing Yang, Peifeng Medicine (Baltimore) 5600 This study aimed to explore the prenatal indicators in the second trimester of pregnancy and their association with chromosome abnormities (CA) to guide decisions toward invasive diagnostic procedures. Pregnant women who underwent prenatal screening and underwent amniocentesis in the second trimester in our Hospital between June 2017 and February 2019 were included in this retrospective cohort study. The reason for amniocentesis in prenatal screening and diagnoses was extracted from the charts. Finally, 3449 pregnant women were included. Of them, 181 were with CA confirmed by amniocentesis (i.e., the CA group), while 3268 were without CA (i.e., the non-CA group). Compared with the women in the non-CA group, those in the CA group were more likely to be older (30 [27,32] vs 29 [26,31], P < .001), had higher gestational weeks (20 [19,23] vs 19 [18,23], P = .008), an increased risk of advanced maternal age (AMA) (9.4% vs 2.2%, P < .001), had an increased risk of NIPT (IRN) (5.1% vs 1.9%, P < .001), had higher rates of a parental chromosome abnormality (PCA) (1.8% vs 0.9%, P = .002), and had increased risk of trisomy 21 (IRT21) (63.0% vs 45.3%, P < .001). AMA (OR = 4.22, 95% CI: 2.35–7.58, P < .001; AUC = 0.536), IRN (OR = 10.62, 95% CI: 6.66–16.94, P < .001; AUC = 0.589), PCA (OR = 4.77, 95% CI: 2.01–11.32, P < .001; AUC = 0.584), and IRT21 (OR = 0.67, 95% CI: 0.47–0.89, P = .008; AUC = 0.515) were independently associated with CA. AMA, IRN, IRT21, and PCA during the second trimester were independently associated with CA, but their predictive values for CA were relatively low. Combining those indicators may improve the predictive value. Lippincott Williams & Wilkins 2023-09-01 /pmc/articles/PMC10476756/ /pubmed/37657051 http://dx.doi.org/10.1097/MD.0000000000034762 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5600
Pan, Ci
Li, Zilong
Cheng, Guomei
Luo, Xiaohua
Nie, Fufang
Gao, Jing
Yang, Peifeng
Association between chromosome abnormities and prenatal diagnosis indicators screening in the second trimester of pregnancy
title Association between chromosome abnormities and prenatal diagnosis indicators screening in the second trimester of pregnancy
title_full Association between chromosome abnormities and prenatal diagnosis indicators screening in the second trimester of pregnancy
title_fullStr Association between chromosome abnormities and prenatal diagnosis indicators screening in the second trimester of pregnancy
title_full_unstemmed Association between chromosome abnormities and prenatal diagnosis indicators screening in the second trimester of pregnancy
title_short Association between chromosome abnormities and prenatal diagnosis indicators screening in the second trimester of pregnancy
title_sort association between chromosome abnormities and prenatal diagnosis indicators screening in the second trimester of pregnancy
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476756/
https://www.ncbi.nlm.nih.gov/pubmed/37657051
http://dx.doi.org/10.1097/MD.0000000000034762
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