Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis

INTRODUCTION: We compared esophageal mucosal gene transcript expression in proton pump inhibitor (PPI) responsive (PPI-R) eosinophilic esophagitis (EoE), PPI nonresponsive (PPI-NR) EoE, and healthy controls. METHODS: Transcript expression in midesophagus biopsies was determined using NanoString and...

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Autores principales: Hamilton, Matthew J., Muftah, Mayssan, Goldin, Alison H., Lo, Wai-Kit, Hsu Blatman, Karen S., Chan, Walter W., Srivastava, Amitabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476787/
https://www.ncbi.nlm.nih.gov/pubmed/36201660
http://dx.doi.org/10.14309/ctg.0000000000000540
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author Hamilton, Matthew J.
Muftah, Mayssan
Goldin, Alison H.
Lo, Wai-Kit
Hsu Blatman, Karen S.
Chan, Walter W.
Srivastava, Amitabh
author_facet Hamilton, Matthew J.
Muftah, Mayssan
Goldin, Alison H.
Lo, Wai-Kit
Hsu Blatman, Karen S.
Chan, Walter W.
Srivastava, Amitabh
author_sort Hamilton, Matthew J.
collection PubMed
description INTRODUCTION: We compared esophageal mucosal gene transcript expression in proton pump inhibitor (PPI) responsive (PPI-R) eosinophilic esophagitis (EoE), PPI nonresponsive (PPI-NR) EoE, and healthy controls. METHODS: Transcript expression in midesophagus biopsies was determined using NanoString and a custom panel of EoE-specific genes. The top upregulated and downregulated genes with ≥2-fold difference in expression and statistically significant (P < 0.05) were identified. RESULTS: Nearly all the top upregulated (17 of 20) and downregulated (5 of 5) genes in EoE, compared with healthy controls, were shared between the PPI-R and PPI-NR groups. DISCUSSION: Esophageal mucosal transcript expressions are remarkably similar in PPI-R EoE and PPI-NR EoE compared with healthy controls.
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spelling pubmed-104767872023-09-05 Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis Hamilton, Matthew J. Muftah, Mayssan Goldin, Alison H. Lo, Wai-Kit Hsu Blatman, Karen S. Chan, Walter W. Srivastava, Amitabh Clin Transl Gastroenterol Brief Report INTRODUCTION: We compared esophageal mucosal gene transcript expression in proton pump inhibitor (PPI) responsive (PPI-R) eosinophilic esophagitis (EoE), PPI nonresponsive (PPI-NR) EoE, and healthy controls. METHODS: Transcript expression in midesophagus biopsies was determined using NanoString and a custom panel of EoE-specific genes. The top upregulated and downregulated genes with ≥2-fold difference in expression and statistically significant (P < 0.05) were identified. RESULTS: Nearly all the top upregulated (17 of 20) and downregulated (5 of 5) genes in EoE, compared with healthy controls, were shared between the PPI-R and PPI-NR groups. DISCUSSION: Esophageal mucosal transcript expressions are remarkably similar in PPI-R EoE and PPI-NR EoE compared with healthy controls. Wolters Kluwer 2022-10-06 /pmc/articles/PMC10476787/ /pubmed/36201660 http://dx.doi.org/10.14309/ctg.0000000000000540 Text en © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Brief Report
Hamilton, Matthew J.
Muftah, Mayssan
Goldin, Alison H.
Lo, Wai-Kit
Hsu Blatman, Karen S.
Chan, Walter W.
Srivastava, Amitabh
Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis
title Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis
title_full Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis
title_fullStr Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis
title_full_unstemmed Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis
title_short Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis
title_sort overlapping transcriptional profile in proton pump inhibitor responsive and nonresponsive eosinophilic esophagitis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476787/
https://www.ncbi.nlm.nih.gov/pubmed/36201660
http://dx.doi.org/10.14309/ctg.0000000000000540
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