The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications

Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor...

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Detalles Bibliográficos
Autores principales: Silva, Jéssica Manoelli Costa, Teixeira, Eliel Barbosa, Mourão, Ronald Matheus da Silva, Ferraz, Rafaella Sousa, Moreira, Fabiano Cordeiro, de Assumpção, Paulo Pimentel, Calcagno, Danielle Queiroz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476871/
https://www.ncbi.nlm.nih.gov/pubmed/37670949
http://dx.doi.org/10.3389/fphar.2023.1237723
Descripción
Sumario:Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.

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