The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications

Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor...

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Autores principales: Silva, Jéssica Manoelli Costa, Teixeira, Eliel Barbosa, Mourão, Ronald Matheus da Silva, Ferraz, Rafaella Sousa, Moreira, Fabiano Cordeiro, de Assumpção, Paulo Pimentel, Calcagno, Danielle Queiroz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476871/
https://www.ncbi.nlm.nih.gov/pubmed/37670949
http://dx.doi.org/10.3389/fphar.2023.1237723
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author Silva, Jéssica Manoelli Costa
Teixeira, Eliel Barbosa
Mourão, Ronald Matheus da Silva
Ferraz, Rafaella Sousa
Moreira, Fabiano Cordeiro
de Assumpção, Paulo Pimentel
Calcagno, Danielle Queiroz
author_facet Silva, Jéssica Manoelli Costa
Teixeira, Eliel Barbosa
Mourão, Ronald Matheus da Silva
Ferraz, Rafaella Sousa
Moreira, Fabiano Cordeiro
de Assumpção, Paulo Pimentel
Calcagno, Danielle Queiroz
author_sort Silva, Jéssica Manoelli Costa
collection PubMed
description Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.
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spelling pubmed-104768712023-09-05 The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications Silva, Jéssica Manoelli Costa Teixeira, Eliel Barbosa Mourão, Ronald Matheus da Silva Ferraz, Rafaella Sousa Moreira, Fabiano Cordeiro de Assumpção, Paulo Pimentel Calcagno, Danielle Queiroz Front Pharmacol Pharmacology Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers. Frontiers Media S.A. 2023-08-21 /pmc/articles/PMC10476871/ /pubmed/37670949 http://dx.doi.org/10.3389/fphar.2023.1237723 Text en Copyright © 2023 Silva, Teixeira, Mourão, Ferraz, Moreira, Assumpção and Calcagno. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Silva, Jéssica Manoelli Costa
Teixeira, Eliel Barbosa
Mourão, Ronald Matheus da Silva
Ferraz, Rafaella Sousa
Moreira, Fabiano Cordeiro
de Assumpção, Paulo Pimentel
Calcagno, Danielle Queiroz
The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications
title The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications
title_full The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications
title_fullStr The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications
title_full_unstemmed The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications
title_short The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications
title_sort landscape of lncrnas in gastric cancer: from molecular mechanisms to potential clinical applications
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476871/
https://www.ncbi.nlm.nih.gov/pubmed/37670949
http://dx.doi.org/10.3389/fphar.2023.1237723
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