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Regulación del calcio por SERC-A antes de la enfermedad de Alzheimer y durante la misma
There are many factors involved in the incidence of Alzheimer’s disease that, in combination, impede or hinder normal neuronal functions. Little is currently known about calcium regulation before and during the disease. Internal instability of calcium levels is associated with increased vascular ris...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Nacional de Salud
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476880/ https://www.ncbi.nlm.nih.gov/pubmed/37167461 http://dx.doi.org/10.7705/biomedica.6704 |
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author | Alwiraikat-Flores, Alamira Farah Octavio-Aguilar, Pablo |
author_facet | Alwiraikat-Flores, Alamira Farah Octavio-Aguilar, Pablo |
author_sort | Alwiraikat-Flores, Alamira Farah |
collection | PubMed |
description | There are many factors involved in the incidence of Alzheimer’s disease that, in combination, impede or hinder normal neuronal functions. Little is currently known about calcium regulation before and during the disease. Internal instability of calcium levels is associated with increased vascular risk, a prevalent condition in a high number of individuals already compromised by Alzheimer’s disease. This review provides a reevaluation of the molecular mechanism of the sarcoendoplasmic reticulum calcium ATPase (SERC-A) in the disease and discusses salient aspects of voltage-gated calcium channel function; in these way new alternatives could be open for its treatment. These regulation mechanisms are clinically relevant since the irregular functions of SERC+A has been implicated in pathologies of brain function. |
format | Online Article Text |
id | pubmed-10476880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Instituto Nacional de Salud |
record_format | MEDLINE/PubMed |
spelling | pubmed-104768802023-09-05 Regulación del calcio por SERC-A antes de la enfermedad de Alzheimer y durante la misma Alwiraikat-Flores, Alamira Farah Octavio-Aguilar, Pablo Biomedica Ensayo There are many factors involved in the incidence of Alzheimer’s disease that, in combination, impede or hinder normal neuronal functions. Little is currently known about calcium regulation before and during the disease. Internal instability of calcium levels is associated with increased vascular risk, a prevalent condition in a high number of individuals already compromised by Alzheimer’s disease. This review provides a reevaluation of the molecular mechanism of the sarcoendoplasmic reticulum calcium ATPase (SERC-A) in the disease and discusses salient aspects of voltage-gated calcium channel function; in these way new alternatives could be open for its treatment. These regulation mechanisms are clinically relevant since the irregular functions of SERC+A has been implicated in pathologies of brain function. Instituto Nacional de Salud 2023-03-30 /pmc/articles/PMC10476880/ /pubmed/37167461 http://dx.doi.org/10.7705/biomedica.6704 Text en https://creativecommons.org/licenses/by/4.0/Este es un artículo publicado en acceso abierto bajo una licencia Creative Commons |
spellingShingle | Ensayo Alwiraikat-Flores, Alamira Farah Octavio-Aguilar, Pablo Regulación del calcio por SERC-A antes de la enfermedad de Alzheimer y durante la misma |
title | Regulación del calcio por SERC-A antes de la enfermedad de Alzheimer y durante la misma |
title_full | Regulación del calcio por SERC-A antes de la enfermedad de Alzheimer y durante la misma |
title_fullStr | Regulación del calcio por SERC-A antes de la enfermedad de Alzheimer y durante la misma |
title_full_unstemmed | Regulación del calcio por SERC-A antes de la enfermedad de Alzheimer y durante la misma |
title_short | Regulación del calcio por SERC-A antes de la enfermedad de Alzheimer y durante la misma |
title_sort | regulación del calcio por serc-a antes de la enfermedad de alzheimer y durante la misma |
topic | Ensayo |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476880/ https://www.ncbi.nlm.nih.gov/pubmed/37167461 http://dx.doi.org/10.7705/biomedica.6704 |
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