More microinvasive foci in larger tumours of breast ductal carcinoma in situ

INTRODUCTION: Microinvasion (Mi) is often thought to be an interim stage between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. This study aimed to investigate the potential influence of Mi on survival and assess its correlations with clinicopathological parameters, prognosis and mol...

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Autores principales: Chen, Xiao-Yang, Thike, Aye Aye, Lim, Johnathan Xiande, Bay, Boon Huat, Tan, Puay Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476920/
https://www.ncbi.nlm.nih.gov/pubmed/35846408
http://dx.doi.org/10.11622/smedj.2022089
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author Chen, Xiao-Yang
Thike, Aye Aye
Lim, Johnathan Xiande
Bay, Boon Huat
Tan, Puay Hoon
author_facet Chen, Xiao-Yang
Thike, Aye Aye
Lim, Johnathan Xiande
Bay, Boon Huat
Tan, Puay Hoon
author_sort Chen, Xiao-Yang
collection PubMed
description INTRODUCTION: Microinvasion (Mi) is often thought to be an interim stage between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. This study aimed to investigate the potential influence of Mi on survival and assess its correlations with clinicopathological parameters, prognosis and molecular markers. METHODS: The number of Mi foci in a cohort of 66 DCIS-Mi cases was assessed from haematoxylin and eosin–stained sections. Disease-free survival, clinicopathological parameters and biomarker expression were correlated with the number of Mi foci. RESULTS: Higher numbers of Mi foci were found in larger tumours (P = 0.031). CONCLUSION: Greater extent of DCIS is associated with multifocal Mi.
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spelling pubmed-104769202023-09-05 More microinvasive foci in larger tumours of breast ductal carcinoma in situ Chen, Xiao-Yang Thike, Aye Aye Lim, Johnathan Xiande Bay, Boon Huat Tan, Puay Hoon Singapore Med J Original Article INTRODUCTION: Microinvasion (Mi) is often thought to be an interim stage between ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. This study aimed to investigate the potential influence of Mi on survival and assess its correlations with clinicopathological parameters, prognosis and molecular markers. METHODS: The number of Mi foci in a cohort of 66 DCIS-Mi cases was assessed from haematoxylin and eosin–stained sections. Disease-free survival, clinicopathological parameters and biomarker expression were correlated with the number of Mi foci. RESULTS: Higher numbers of Mi foci were found in larger tumours (P = 0.031). CONCLUSION: Greater extent of DCIS is associated with multifocal Mi. Wolters Kluwer - Medknow 2022-07-18 /pmc/articles/PMC10476920/ /pubmed/35846408 http://dx.doi.org/10.11622/smedj.2022089 Text en Copyright: © 2023 Singapore Medical Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Chen, Xiao-Yang
Thike, Aye Aye
Lim, Johnathan Xiande
Bay, Boon Huat
Tan, Puay Hoon
More microinvasive foci in larger tumours of breast ductal carcinoma in situ
title More microinvasive foci in larger tumours of breast ductal carcinoma in situ
title_full More microinvasive foci in larger tumours of breast ductal carcinoma in situ
title_fullStr More microinvasive foci in larger tumours of breast ductal carcinoma in situ
title_full_unstemmed More microinvasive foci in larger tumours of breast ductal carcinoma in situ
title_short More microinvasive foci in larger tumours of breast ductal carcinoma in situ
title_sort more microinvasive foci in larger tumours of breast ductal carcinoma in situ
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476920/
https://www.ncbi.nlm.nih.gov/pubmed/35846408
http://dx.doi.org/10.11622/smedj.2022089
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AT limjohnathanxiande moremicroinvasivefociinlargertumoursofbreastductalcarcinomainsitu
AT bayboonhuat moremicroinvasivefociinlargertumoursofbreastductalcarcinomainsitu
AT tanpuayhoon moremicroinvasivefociinlargertumoursofbreastductalcarcinomainsitu

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