Cargando…
Abstract 10 Experience with Enrollments and Releases Within a Medical Needs Program at a Large U.S. Private Cord Blood Bank
INTRODUCTION: Medical Needs / Directed Donor programs provide families with access to cord blood for potential future use. In situations where a diagnosis, potentially treatable with cord blood, exists in an immediate relative of the newborn, these programs often allow families to preserve newborn s...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476959/ http://dx.doi.org/10.1093/stcltm/szad047.011 |
_version_ | 1785101044352548864 |
---|---|
author | Fernekes, Michelle Brown, Heather Pandolfi, Erica Stroh, Eliza Isley, Lauren |
author_facet | Fernekes, Michelle Brown, Heather Pandolfi, Erica Stroh, Eliza Isley, Lauren |
author_sort | Fernekes, Michelle |
collection | PubMed |
description | INTRODUCTION: Medical Needs / Directed Donor programs provide families with access to cord blood for potential future use. In situations where a diagnosis, potentially treatable with cord blood, exists in an immediate relative of the newborn, these programs often allow families to preserve newborn stem cells at little to no cost. OBJECTIVES: The objective of this study was to examine indications for enrollment and unit releases in a medical needs program at a large U.S. private newborn stem cell bank. METHODS: Enrollment data over a 24-year period was analyzed. Data was categorized by indications for enrollment and indications for which units were released. RESULTS: There was a total of 7,034 enrollments within the specified timeframe. Most enrollments were for indications treatable by hematopoietic stem cell transplant given the program did not include experimental indications until 2019. Approximately one-third of enrollments (33.4%) for transplant indications were for various types of leukemia. The experimental indications most frequently represented in enrollments were autism (44.3%) and cerebral palsy (38.4%). For all cord blood units stored under the medical needs program, the majority (70%) of releases were intended for use in transplant medicine. The most frequently represented transplant indication for releases was hemoglobinopathies including sickle cell anemia and beta thalassemia (44.6%). Approximately one-third (36.1%) of transplant releases were related to leukemia. Autism and cerebral palsy were the two most frequently represented experimental indications for units released at 39% and 36%, respectively. DISCUSSION: Clinical indications were mostly consistent between enrollments and releases through this cohort. This suggests the structure of the program is effective in identifying families who have a higher likelihood of utilizing their cord blood unit for a transplant or experimental infusion. Cord blood banks should continue to re-evaluate the eligibility criteria for their medical needs programs in light of relevant updates in the potential utility of newborn stem cells including changes in transplant medicine indications and treatment procedures, as well as clinical trials and experimental protocols using related cord blood units. Future research related to pathways of referral to medical needs programs may inform education gaps among women’s health providers. |
format | Online Article Text |
id | pubmed-10476959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-104769592023-09-05 Abstract 10 Experience with Enrollments and Releases Within a Medical Needs Program at a Large U.S. Private Cord Blood Bank Fernekes, Michelle Brown, Heather Pandolfi, Erica Stroh, Eliza Isley, Lauren Stem Cells Transl Med Cord Blood Bank Management, Administration and Sustainability INTRODUCTION: Medical Needs / Directed Donor programs provide families with access to cord blood for potential future use. In situations where a diagnosis, potentially treatable with cord blood, exists in an immediate relative of the newborn, these programs often allow families to preserve newborn stem cells at little to no cost. OBJECTIVES: The objective of this study was to examine indications for enrollment and unit releases in a medical needs program at a large U.S. private newborn stem cell bank. METHODS: Enrollment data over a 24-year period was analyzed. Data was categorized by indications for enrollment and indications for which units were released. RESULTS: There was a total of 7,034 enrollments within the specified timeframe. Most enrollments were for indications treatable by hematopoietic stem cell transplant given the program did not include experimental indications until 2019. Approximately one-third of enrollments (33.4%) for transplant indications were for various types of leukemia. The experimental indications most frequently represented in enrollments were autism (44.3%) and cerebral palsy (38.4%). For all cord blood units stored under the medical needs program, the majority (70%) of releases were intended for use in transplant medicine. The most frequently represented transplant indication for releases was hemoglobinopathies including sickle cell anemia and beta thalassemia (44.6%). Approximately one-third (36.1%) of transplant releases were related to leukemia. Autism and cerebral palsy were the two most frequently represented experimental indications for units released at 39% and 36%, respectively. DISCUSSION: Clinical indications were mostly consistent between enrollments and releases through this cohort. This suggests the structure of the program is effective in identifying families who have a higher likelihood of utilizing their cord blood unit for a transplant or experimental infusion. Cord blood banks should continue to re-evaluate the eligibility criteria for their medical needs programs in light of relevant updates in the potential utility of newborn stem cells including changes in transplant medicine indications and treatment procedures, as well as clinical trials and experimental protocols using related cord blood units. Future research related to pathways of referral to medical needs programs may inform education gaps among women’s health providers. Oxford University Press 2023-09-04 /pmc/articles/PMC10476959/ http://dx.doi.org/10.1093/stcltm/szad047.011 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Cord Blood Bank Management, Administration and Sustainability Fernekes, Michelle Brown, Heather Pandolfi, Erica Stroh, Eliza Isley, Lauren Abstract 10 Experience with Enrollments and Releases Within a Medical Needs Program at a Large U.S. Private Cord Blood Bank |
title | Abstract 10 Experience with Enrollments and Releases Within a Medical Needs Program at a Large U.S. Private Cord Blood Bank |
title_full | Abstract 10 Experience with Enrollments and Releases Within a Medical Needs Program at a Large U.S. Private Cord Blood Bank |
title_fullStr | Abstract 10 Experience with Enrollments and Releases Within a Medical Needs Program at a Large U.S. Private Cord Blood Bank |
title_full_unstemmed | Abstract 10 Experience with Enrollments and Releases Within a Medical Needs Program at a Large U.S. Private Cord Blood Bank |
title_short | Abstract 10 Experience with Enrollments and Releases Within a Medical Needs Program at a Large U.S. Private Cord Blood Bank |
title_sort | abstract 10 experience with enrollments and releases within a medical needs program at a large u.s. private cord blood bank |
topic | Cord Blood Bank Management, Administration and Sustainability |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476959/ http://dx.doi.org/10.1093/stcltm/szad047.011 |
work_keys_str_mv | AT fernekesmichelle abstract10experiencewithenrollmentsandreleaseswithinamedicalneedsprogramatalargeusprivatecordbloodbank AT brownheather abstract10experiencewithenrollmentsandreleaseswithinamedicalneedsprogramatalargeusprivatecordbloodbank AT pandolfierica abstract10experiencewithenrollmentsandreleaseswithinamedicalneedsprogramatalargeusprivatecordbloodbank AT stroheliza abstract10experiencewithenrollmentsandreleaseswithinamedicalneedsprogramatalargeusprivatecordbloodbank AT isleylauren abstract10experiencewithenrollmentsandreleaseswithinamedicalneedsprogramatalargeusprivatecordbloodbank |