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Clinical feasibility of a commercially available MRI‐only method for radiotherapy treatment planning of the brain

BACKGROUND: Advancements in deep‐learning based synthetic computed tomography (sCT) image conversion methods have enabled the development of magnetic resonance imaging (MRI)‐only based radiotherapy treatment planning (RTP) of the brain. PURPOSE: This study evaluates the clinical feasibility of a com...

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Autores principales: Ranta, Iiro, Wright, Pauliina, Suilamo, Sami, Kemppainen, Reko, Schubert, Gerald, Kapanen, Mika, Keyriläinen, Jani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476982/
https://www.ncbi.nlm.nih.gov/pubmed/37345212
http://dx.doi.org/10.1002/acm2.14044
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author Ranta, Iiro
Wright, Pauliina
Suilamo, Sami
Kemppainen, Reko
Schubert, Gerald
Kapanen, Mika
Keyriläinen, Jani
author_facet Ranta, Iiro
Wright, Pauliina
Suilamo, Sami
Kemppainen, Reko
Schubert, Gerald
Kapanen, Mika
Keyriläinen, Jani
author_sort Ranta, Iiro
collection PubMed
description BACKGROUND: Advancements in deep‐learning based synthetic computed tomography (sCT) image conversion methods have enabled the development of magnetic resonance imaging (MRI)‐only based radiotherapy treatment planning (RTP) of the brain. PURPOSE: This study evaluates the clinical feasibility of a commercial, deep‐learning based MRI‐only RTP method with respect to dose calculation and patient positioning verification performance in RTP of the brain. METHODS: Clinical validation of dose calculation accuracy was performed by a retrospective evaluation for 25 glioma and 25 brain metastasis patients. Dosimetric and image quality of the studied MRI‐only RTP method was evaluated by a direct comparison of the sCT‐based and computed tomography (CT)‐based external beam radiation therapy (EBRT) images and treatment plans. Patient positioning verification accuracy of sCT images was evaluated retrospectively for 10 glioma and 10 brain metastasis patients based on clinical cone‐beam computed tomography (CBCT) imaging. RESULTS: An average mean dose difference of D (mean) = 0.1% for planning target volume (PTV) and 0.6% for normal tissue (NT) structures were obtained for glioma patients. Respective results for brain metastasis patients were D (mean) = 0.5% for PTVs and D (mean)=1.0% for NTs. Global three‐dimensional (3D) gamma pass rates using 2%/2 mm dose difference and distance‐to‐agreement (DTA) criterion were 98.0% for the glioma subgroup, and 95.2% for the brain metastasis subgroup using 1%/1 mm criterion. Mean distance differences of <1.0 mm were observed in all Cartesian directions between CT‐based and sCT‐based CBCT patient positioning in both subgroups. CONCLUSIONS: In terms of dose calculation and patient positioning accuracy, the studied MRI‐only method demonstrated its clinical feasibility for RTP of the brain. The results encourage the use of the studied method as part of a routine clinical workflow.
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spelling pubmed-104769822023-09-05 Clinical feasibility of a commercially available MRI‐only method for radiotherapy treatment planning of the brain Ranta, Iiro Wright, Pauliina Suilamo, Sami Kemppainen, Reko Schubert, Gerald Kapanen, Mika Keyriläinen, Jani J Appl Clin Med Phys Radiation Oncology Physics BACKGROUND: Advancements in deep‐learning based synthetic computed tomography (sCT) image conversion methods have enabled the development of magnetic resonance imaging (MRI)‐only based radiotherapy treatment planning (RTP) of the brain. PURPOSE: This study evaluates the clinical feasibility of a commercial, deep‐learning based MRI‐only RTP method with respect to dose calculation and patient positioning verification performance in RTP of the brain. METHODS: Clinical validation of dose calculation accuracy was performed by a retrospective evaluation for 25 glioma and 25 brain metastasis patients. Dosimetric and image quality of the studied MRI‐only RTP method was evaluated by a direct comparison of the sCT‐based and computed tomography (CT)‐based external beam radiation therapy (EBRT) images and treatment plans. Patient positioning verification accuracy of sCT images was evaluated retrospectively for 10 glioma and 10 brain metastasis patients based on clinical cone‐beam computed tomography (CBCT) imaging. RESULTS: An average mean dose difference of D (mean) = 0.1% for planning target volume (PTV) and 0.6% for normal tissue (NT) structures were obtained for glioma patients. Respective results for brain metastasis patients were D (mean) = 0.5% for PTVs and D (mean)=1.0% for NTs. Global three‐dimensional (3D) gamma pass rates using 2%/2 mm dose difference and distance‐to‐agreement (DTA) criterion were 98.0% for the glioma subgroup, and 95.2% for the brain metastasis subgroup using 1%/1 mm criterion. Mean distance differences of <1.0 mm were observed in all Cartesian directions between CT‐based and sCT‐based CBCT patient positioning in both subgroups. CONCLUSIONS: In terms of dose calculation and patient positioning accuracy, the studied MRI‐only method demonstrated its clinical feasibility for RTP of the brain. The results encourage the use of the studied method as part of a routine clinical workflow. John Wiley and Sons Inc. 2023-06-21 /pmc/articles/PMC10476982/ /pubmed/37345212 http://dx.doi.org/10.1002/acm2.14044 Text en © 2023 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, LLC on behalf of The American Association of Physicists in Medicine. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Ranta, Iiro
Wright, Pauliina
Suilamo, Sami
Kemppainen, Reko
Schubert, Gerald
Kapanen, Mika
Keyriläinen, Jani
Clinical feasibility of a commercially available MRI‐only method for radiotherapy treatment planning of the brain
title Clinical feasibility of a commercially available MRI‐only method for radiotherapy treatment planning of the brain
title_full Clinical feasibility of a commercially available MRI‐only method for radiotherapy treatment planning of the brain
title_fullStr Clinical feasibility of a commercially available MRI‐only method for radiotherapy treatment planning of the brain
title_full_unstemmed Clinical feasibility of a commercially available MRI‐only method for radiotherapy treatment planning of the brain
title_short Clinical feasibility of a commercially available MRI‐only method for radiotherapy treatment planning of the brain
title_sort clinical feasibility of a commercially available mri‐only method for radiotherapy treatment planning of the brain
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476982/
https://www.ncbi.nlm.nih.gov/pubmed/37345212
http://dx.doi.org/10.1002/acm2.14044
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