Cargando…
Decision and response monitoring during working memory are sequentially represented in the human insula
Emerging research supports a role of the insula in human cognition. Here, we used intracranial EEG to investigate the spatiotemporal dynamics in the insula during a verbal working memory (vWM) task. We found robust effects for theta, beta, and high frequency activity (HFA) during probe presentation...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477069/ https://www.ncbi.nlm.nih.gov/pubmed/37674986 http://dx.doi.org/10.1016/j.isci.2023.107653 |
_version_ | 1785101065786490880 |
---|---|
author | Llorens, Anaïs Bellier, Ludovic Blenkmann, Alejandro O. Ivanovic, Jugoslav Larsson, Pål G. Lin, Jack J. Endestad, Tor Solbakk, Anne-Kristin Knight, Robert T. |
author_facet | Llorens, Anaïs Bellier, Ludovic Blenkmann, Alejandro O. Ivanovic, Jugoslav Larsson, Pål G. Lin, Jack J. Endestad, Tor Solbakk, Anne-Kristin Knight, Robert T. |
author_sort | Llorens, Anaïs |
collection | PubMed |
description | Emerging research supports a role of the insula in human cognition. Here, we used intracranial EEG to investigate the spatiotemporal dynamics in the insula during a verbal working memory (vWM) task. We found robust effects for theta, beta, and high frequency activity (HFA) during probe presentation requiring a decision. Theta band activity showed differential involvement across left and right insulae while sequential HFA modulations were observed along the anteroposterior axis. HFA in anterior insula tracked decision making and subsequent HFA was observed in posterior insula after the behavioral response. Our results provide electrophysiological evidence of engagement of different insula subregions in both decision-making and response monitoring during vWM and expand our knowledge of the role of the insula in complex human behavior. |
format | Online Article Text |
id | pubmed-10477069 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-104770692023-09-06 Decision and response monitoring during working memory are sequentially represented in the human insula Llorens, Anaïs Bellier, Ludovic Blenkmann, Alejandro O. Ivanovic, Jugoslav Larsson, Pål G. Lin, Jack J. Endestad, Tor Solbakk, Anne-Kristin Knight, Robert T. iScience Article Emerging research supports a role of the insula in human cognition. Here, we used intracranial EEG to investigate the spatiotemporal dynamics in the insula during a verbal working memory (vWM) task. We found robust effects for theta, beta, and high frequency activity (HFA) during probe presentation requiring a decision. Theta band activity showed differential involvement across left and right insulae while sequential HFA modulations were observed along the anteroposterior axis. HFA in anterior insula tracked decision making and subsequent HFA was observed in posterior insula after the behavioral response. Our results provide electrophysiological evidence of engagement of different insula subregions in both decision-making and response monitoring during vWM and expand our knowledge of the role of the insula in complex human behavior. Elsevier 2023-08-17 /pmc/articles/PMC10477069/ /pubmed/37674986 http://dx.doi.org/10.1016/j.isci.2023.107653 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Llorens, Anaïs Bellier, Ludovic Blenkmann, Alejandro O. Ivanovic, Jugoslav Larsson, Pål G. Lin, Jack J. Endestad, Tor Solbakk, Anne-Kristin Knight, Robert T. Decision and response monitoring during working memory are sequentially represented in the human insula |
title | Decision and response monitoring during working memory are sequentially represented in the human insula |
title_full | Decision and response monitoring during working memory are sequentially represented in the human insula |
title_fullStr | Decision and response monitoring during working memory are sequentially represented in the human insula |
title_full_unstemmed | Decision and response monitoring during working memory are sequentially represented in the human insula |
title_short | Decision and response monitoring during working memory are sequentially represented in the human insula |
title_sort | decision and response monitoring during working memory are sequentially represented in the human insula |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477069/ https://www.ncbi.nlm.nih.gov/pubmed/37674986 http://dx.doi.org/10.1016/j.isci.2023.107653 |
work_keys_str_mv | AT llorensanais decisionandresponsemonitoringduringworkingmemoryaresequentiallyrepresentedinthehumaninsula AT bellierludovic decisionandresponsemonitoringduringworkingmemoryaresequentiallyrepresentedinthehumaninsula AT blenkmannalejandroo decisionandresponsemonitoringduringworkingmemoryaresequentiallyrepresentedinthehumaninsula AT ivanovicjugoslav decisionandresponsemonitoringduringworkingmemoryaresequentiallyrepresentedinthehumaninsula AT larssonpalg decisionandresponsemonitoringduringworkingmemoryaresequentiallyrepresentedinthehumaninsula AT linjackj decisionandresponsemonitoringduringworkingmemoryaresequentiallyrepresentedinthehumaninsula AT endestadtor decisionandresponsemonitoringduringworkingmemoryaresequentiallyrepresentedinthehumaninsula AT solbakkannekristin decisionandresponsemonitoringduringworkingmemoryaresequentiallyrepresentedinthehumaninsula AT knightrobertt decisionandresponsemonitoringduringworkingmemoryaresequentiallyrepresentedinthehumaninsula |