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Decision and response monitoring during working memory are sequentially represented in the human insula

Emerging research supports a role of the insula in human cognition. Here, we used intracranial EEG to investigate the spatiotemporal dynamics in the insula during a verbal working memory (vWM) task. We found robust effects for theta, beta, and high frequency activity (HFA) during probe presentation...

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Detalles Bibliográficos
Autores principales: Llorens, Anaïs, Bellier, Ludovic, Blenkmann, Alejandro O., Ivanovic, Jugoslav, Larsson, Pål G., Lin, Jack J., Endestad, Tor, Solbakk, Anne-Kristin, Knight, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477069/
https://www.ncbi.nlm.nih.gov/pubmed/37674986
http://dx.doi.org/10.1016/j.isci.2023.107653
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author Llorens, Anaïs
Bellier, Ludovic
Blenkmann, Alejandro O.
Ivanovic, Jugoslav
Larsson, Pål G.
Lin, Jack J.
Endestad, Tor
Solbakk, Anne-Kristin
Knight, Robert T.
author_facet Llorens, Anaïs
Bellier, Ludovic
Blenkmann, Alejandro O.
Ivanovic, Jugoslav
Larsson, Pål G.
Lin, Jack J.
Endestad, Tor
Solbakk, Anne-Kristin
Knight, Robert T.
author_sort Llorens, Anaïs
collection PubMed
description Emerging research supports a role of the insula in human cognition. Here, we used intracranial EEG to investigate the spatiotemporal dynamics in the insula during a verbal working memory (vWM) task. We found robust effects for theta, beta, and high frequency activity (HFA) during probe presentation requiring a decision. Theta band activity showed differential involvement across left and right insulae while sequential HFA modulations were observed along the anteroposterior axis. HFA in anterior insula tracked decision making and subsequent HFA was observed in posterior insula after the behavioral response. Our results provide electrophysiological evidence of engagement of different insula subregions in both decision-making and response monitoring during vWM and expand our knowledge of the role of the insula in complex human behavior.
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spelling pubmed-104770692023-09-06 Decision and response monitoring during working memory are sequentially represented in the human insula Llorens, Anaïs Bellier, Ludovic Blenkmann, Alejandro O. Ivanovic, Jugoslav Larsson, Pål G. Lin, Jack J. Endestad, Tor Solbakk, Anne-Kristin Knight, Robert T. iScience Article Emerging research supports a role of the insula in human cognition. Here, we used intracranial EEG to investigate the spatiotemporal dynamics in the insula during a verbal working memory (vWM) task. We found robust effects for theta, beta, and high frequency activity (HFA) during probe presentation requiring a decision. Theta band activity showed differential involvement across left and right insulae while sequential HFA modulations were observed along the anteroposterior axis. HFA in anterior insula tracked decision making and subsequent HFA was observed in posterior insula after the behavioral response. Our results provide electrophysiological evidence of engagement of different insula subregions in both decision-making and response monitoring during vWM and expand our knowledge of the role of the insula in complex human behavior. Elsevier 2023-08-17 /pmc/articles/PMC10477069/ /pubmed/37674986 http://dx.doi.org/10.1016/j.isci.2023.107653 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Llorens, Anaïs
Bellier, Ludovic
Blenkmann, Alejandro O.
Ivanovic, Jugoslav
Larsson, Pål G.
Lin, Jack J.
Endestad, Tor
Solbakk, Anne-Kristin
Knight, Robert T.
Decision and response monitoring during working memory are sequentially represented in the human insula
title Decision and response monitoring during working memory are sequentially represented in the human insula
title_full Decision and response monitoring during working memory are sequentially represented in the human insula
title_fullStr Decision and response monitoring during working memory are sequentially represented in the human insula
title_full_unstemmed Decision and response monitoring during working memory are sequentially represented in the human insula
title_short Decision and response monitoring during working memory are sequentially represented in the human insula
title_sort decision and response monitoring during working memory are sequentially represented in the human insula
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477069/
https://www.ncbi.nlm.nih.gov/pubmed/37674986
http://dx.doi.org/10.1016/j.isci.2023.107653
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