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Survival in an era of organ preservation: an update on laryngeal cancer in Ireland

BACKGROUND: Laryngeal cancer epidemiology has changed in recent years, with falling incidence observed internationally. Organ preservation therapies have revolutionised management, though some patients may be unsuitable and survival was noted to fall in the 2000s. This study examines trends in laryn...

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Autores principales: Sexton, Gerard P., Walsh, Paul, Moriarty, Frank, Lennon, Paul, O’Neill, James Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477096/
https://www.ncbi.nlm.nih.gov/pubmed/37326667
http://dx.doi.org/10.1007/s00405-023-08055-0
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author Sexton, Gerard P.
Walsh, Paul
Moriarty, Frank
Lennon, Paul
O’Neill, James Paul
author_facet Sexton, Gerard P.
Walsh, Paul
Moriarty, Frank
Lennon, Paul
O’Neill, James Paul
author_sort Sexton, Gerard P.
collection PubMed
description BACKGROUND: Laryngeal cancer epidemiology has changed in recent years, with falling incidence observed internationally. Organ preservation therapies have revolutionised management, though some patients may be unsuitable and survival was noted to fall in the 2000s. This study examines trends in laryngeal cancer in Ireland. METHODS: A retrospective cohort study of National Cancer Registry of Ireland data from 1994 to 2014. RESULTS: From a cohort of 2651, glottic disease was most common (62%, n = 1646). Incidence rose to 3.43 cases/100,000/year for 2010–2014. 5-year disease-specific survival (DSS) was 60.6% and did not change significantly over time. Overall survival (OS) for T3 disease managed with primary radiotherapy was similar to primary surgery (HR 0.98, p = 0.9). DSS for T3 disease improved with primary radiotherapy (HR 0.72, p = 0.045). CONCLUSION: Incidence of laryngeal cancer in Ireland rose despite international trends, while survival changed little. Radiotherapy improves DSS for T3 disease but does not improve OS, possibly secondary to poor organ function post-radiotherapy.
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spelling pubmed-104770962023-09-06 Survival in an era of organ preservation: an update on laryngeal cancer in Ireland Sexton, Gerard P. Walsh, Paul Moriarty, Frank Lennon, Paul O’Neill, James Paul Eur Arch Otorhinolaryngol Head and Neck BACKGROUND: Laryngeal cancer epidemiology has changed in recent years, with falling incidence observed internationally. Organ preservation therapies have revolutionised management, though some patients may be unsuitable and survival was noted to fall in the 2000s. This study examines trends in laryngeal cancer in Ireland. METHODS: A retrospective cohort study of National Cancer Registry of Ireland data from 1994 to 2014. RESULTS: From a cohort of 2651, glottic disease was most common (62%, n = 1646). Incidence rose to 3.43 cases/100,000/year for 2010–2014. 5-year disease-specific survival (DSS) was 60.6% and did not change significantly over time. Overall survival (OS) for T3 disease managed with primary radiotherapy was similar to primary surgery (HR 0.98, p = 0.9). DSS for T3 disease improved with primary radiotherapy (HR 0.72, p = 0.045). CONCLUSION: Incidence of laryngeal cancer in Ireland rose despite international trends, while survival changed little. Radiotherapy improves DSS for T3 disease but does not improve OS, possibly secondary to poor organ function post-radiotherapy. Springer Berlin Heidelberg 2023-06-16 2023 /pmc/articles/PMC10477096/ /pubmed/37326667 http://dx.doi.org/10.1007/s00405-023-08055-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Head and Neck
Sexton, Gerard P.
Walsh, Paul
Moriarty, Frank
Lennon, Paul
O’Neill, James Paul
Survival in an era of organ preservation: an update on laryngeal cancer in Ireland
title Survival in an era of organ preservation: an update on laryngeal cancer in Ireland
title_full Survival in an era of organ preservation: an update on laryngeal cancer in Ireland
title_fullStr Survival in an era of organ preservation: an update on laryngeal cancer in Ireland
title_full_unstemmed Survival in an era of organ preservation: an update on laryngeal cancer in Ireland
title_short Survival in an era of organ preservation: an update on laryngeal cancer in Ireland
title_sort survival in an era of organ preservation: an update on laryngeal cancer in ireland
topic Head and Neck
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477096/
https://www.ncbi.nlm.nih.gov/pubmed/37326667
http://dx.doi.org/10.1007/s00405-023-08055-0
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