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Imipenem/funobactam (formerly XNW4107) in vivo pharmacodynamics against serine carbapenemase-producing Gram-negative bacteria: a novel modelling approach for time-dependent killing

BACKGROUND: Imipenem/funobactam (formerly XNW4107) is a novel β-lactam/β-lactamase inhibitor with activity against MDR Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales strains. Using a neutropenic murine thigh infection model, we aimed to determine the pharmacokinetic/pharmacodyn...

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Detalles Bibliográficos
Autores principales:	Fratoni, Andrew J, Berry, Angela V, Liu, Xiao, Chen, Xi, Wu, Yuchuan, Nicolau, David P, Abdelraouf, Kamilia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477119/ https://www.ncbi.nlm.nih.gov/pubmed/37667103 http://dx.doi.org/10.1093/jac/dkad242

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