The Mechanisms of Ferroptosis Under Hypoxia

Ferroptosis is a new form of programmed cell death, which is characterized by the iron-dependent accumulation of lipid peroxidation and increase of ROS, resulting in oxidative stress and cell death. Iron, lipid, and multiple signaling pathways precisely control the occurrence and implementation of f...

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Autores principales: Gao, Xin, Hu, Wei, Qian, Dianlun, Bai, Xiangfeng, He, Huilin, Li, Lin, Sun, Shibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Review Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477166/
https://www.ncbi.nlm.nih.gov/pubmed/37458878
http://dx.doi.org/10.1007/s10571-023-01388-8
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author Gao, Xin
Hu, Wei
Qian, Dianlun
Bai, Xiangfeng
He, Huilin
Li, Lin
Sun, Shibo
author_facet Gao, Xin
Hu, Wei
Qian, Dianlun
Bai, Xiangfeng
He, Huilin
Li, Lin
Sun, Shibo
author_sort Gao, Xin
collection PubMed
description Ferroptosis is a new form of programmed cell death, which is characterized by the iron-dependent accumulation of lipid peroxidation and increase of ROS, resulting in oxidative stress and cell death. Iron, lipid, and multiple signaling pathways precisely control the occurrence and implementation of ferroptosis. The pathways mainly include Nrf2/HO-1 signaling pathway, p62/Keap1/Nrf2 signaling pathway. Activating p62/Keap1/Nrf2 signaling pathway inhibits ferroptosis. Nrf2/HO-1 signaling pathway promotes ferroptosis. Furthermore, some factors also participate in the occurrence of ferroptosis under hypoxia, such as HIF-1, NCOA4, DMT1. Meanwhile, ferroptosis is related with hypoxia-related diseases, such as MIRI, cancers, and AKI. Accordingly, ferroptosis appears to be a therapeutic target for hypoxia-related diseases.
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spelling pubmed-104771662023-09-06 The Mechanisms of Ferroptosis Under Hypoxia Gao, Xin Hu, Wei Qian, Dianlun Bai, Xiangfeng He, Huilin Li, Lin Sun, Shibo Cell Mol Neurobiol Review Paper Ferroptosis is a new form of programmed cell death, which is characterized by the iron-dependent accumulation of lipid peroxidation and increase of ROS, resulting in oxidative stress and cell death. Iron, lipid, and multiple signaling pathways precisely control the occurrence and implementation of ferroptosis. The pathways mainly include Nrf2/HO-1 signaling pathway, p62/Keap1/Nrf2 signaling pathway. Activating p62/Keap1/Nrf2 signaling pathway inhibits ferroptosis. Nrf2/HO-1 signaling pathway promotes ferroptosis. Furthermore, some factors also participate in the occurrence of ferroptosis under hypoxia, such as HIF-1, NCOA4, DMT1. Meanwhile, ferroptosis is related with hypoxia-related diseases, such as MIRI, cancers, and AKI. Accordingly, ferroptosis appears to be a therapeutic target for hypoxia-related diseases. Springer US 2023-07-17 2023 /pmc/articles/PMC10477166/ /pubmed/37458878 http://dx.doi.org/10.1007/s10571-023-01388-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Paper
Gao, Xin
Hu, Wei
Qian, Dianlun
Bai, Xiangfeng
He, Huilin
Li, Lin
Sun, Shibo
The Mechanisms of Ferroptosis Under Hypoxia
title The Mechanisms of Ferroptosis Under Hypoxia
title_full The Mechanisms of Ferroptosis Under Hypoxia
title_fullStr The Mechanisms of Ferroptosis Under Hypoxia
title_full_unstemmed The Mechanisms of Ferroptosis Under Hypoxia
title_short The Mechanisms of Ferroptosis Under Hypoxia
title_sort mechanisms of ferroptosis under hypoxia
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477166/
https://www.ncbi.nlm.nih.gov/pubmed/37458878
http://dx.doi.org/10.1007/s10571-023-01388-8
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