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In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma

Interferon-gamma (IFN-γ) exerts anti-tumor effects by inducing ferroptosis. Based on CRISPR/Cas9 knockout screening targeting genome-wide protein encoding genes in HepG2 and SK-Hep-1 cell lines, we found that cAMP response element-binding protein (CREB) regulated transcription coactivator 3 (CRTC3)...

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Detalles Bibliográficos
Autores principales:	Li, Li, Xing, Tao, Chen, Yiran, Xu, Weiran, Fan, Bo, Ju, Gaoda, Zhao, Jing, Lin, Li, Yan, Cihui, Liang, Jun, Ren, Xiubao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477178/ https://www.ncbi.nlm.nih.gov/pubmed/37666810 http://dx.doi.org/10.1038/s41420-023-01630-8

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