Lrig1-expression confers suppressive function to CD4(+) cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis

Regulatory T cells (T(reg)) are CD4(+) T cells with immune-suppressive function, which is defined by Foxp3 expression. However, the molecular determinants defining the suppressive population of T cells have yet to be discovered. Here we report that the cell surface protein Lrig1 is enriched in suppr...

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Detalles Bibliográficos
Autores principales: Moon, Jae-Seung, Ho, Chun-Chang, Park, Jong-Hyun, Park, Kyungsoo, Shin, Bo-Young, Lee, Su-Hyeon, Sequeira, Ines, Mun, Chin Hee, Shin, Jin-Su, Kim, Jung-Ho, Kim, Beom Seok, Noh, Jin-Wook, Lee, Eui-Seon, Son, Ji Young, Kim, Yuna, lee, Yeji, Cho, Hee, So, SunHyeon, Park, Jiyoon, Choi, Eunsu, Oh, Jong-Won, Lee, Sang-Won, Morio, Tomohiro, Watt, Fiona M., Seong, Rho Hyun, Lee, Sang-Kyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477202/
https://www.ncbi.nlm.nih.gov/pubmed/37666819
http://dx.doi.org/10.1038/s41467-023-40986-4

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