Laser-Induced Axotomy of Human iPSC-Derived and Murine Primary Neurons Decreases Somatic Tau and AT8 Tau Phosphorylation: A Single-Cell Approach to Study Effects of Acute Axonal Damage

The microtubule-associated protein Tau is highly enriched in axons of brain neurons where it regulates axonal outgrowth, plasticity, and transport. Efficient axonal Tau sorting is critical since somatodendritic Tau missorting is a major hallmark of Alzheimer’s disease and other tauopathies. However,...

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Detalles Bibliográficos
Autores principales: Bell-Simons, M., Buchholz, S., Klimek, J., Zempel, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477226/
https://www.ncbi.nlm.nih.gov/pubmed/37171549
http://dx.doi.org/10.1007/s10571-023-01359-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477226/
https://www.ncbi.nlm.nih.gov/pubmed/37171549
http://dx.doi.org/10.1007/s10571-023-01359-z

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