Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39

Pharmacologic depletion of RNA-binding motif 39 (RBM39) using aryl sulfonamides represents a promising anti-cancer therapy but requires high levels of the adaptor protein DCAF15. Consequently, novel approaches to deplete RBM39 in an DCAF15-independent manner are required. Here, we uncover that RBM39...

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Detalles Bibliográficos
Autores principales: Campagne, Sébastien, Jutzi, Daniel, Malard, Florian, Matoga, Maja, Romane, Ksenija, Feldmuller, Miki, Colombo, Martino, Ruepp, Marc-David, Allain, Frédéric H-T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477243/
https://www.ncbi.nlm.nih.gov/pubmed/37666821
http://dx.doi.org/10.1038/s41467-023-40254-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477243/
https://www.ncbi.nlm.nih.gov/pubmed/37666821
http://dx.doi.org/10.1038/s41467-023-40254-5

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