The role and implication of autophagy in cholangiocarcinoma

Cholangiocarcinoma (CCA) is a malignant tumor that originates from the biliary epithelial cells. It is characterized by a difficult diagnosis and limited treatment options. Autophagy is a cellular survival mechanism that maintains nutrient and energy homeostasis and eliminates intracellular pathogen...

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Detalles Bibliográficos
Autores principales: Khizar, Hayat, Hu, Yufei, Wu, Yanhua, Yang, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477247/
https://www.ncbi.nlm.nih.gov/pubmed/37666811
http://dx.doi.org/10.1038/s41420-023-01631-7
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author Khizar, Hayat
Hu, Yufei
Wu, Yanhua
Yang, Jianfeng
author_facet Khizar, Hayat
Hu, Yufei
Wu, Yanhua
Yang, Jianfeng
author_sort Khizar, Hayat
collection PubMed
description Cholangiocarcinoma (CCA) is a malignant tumor that originates from the biliary epithelial cells. It is characterized by a difficult diagnosis and limited treatment options. Autophagy is a cellular survival mechanism that maintains nutrient and energy homeostasis and eliminates intracellular pathogens. It is involved in various physiological and pathological processes, including the development of cancer. However, the role, mechanism, and potential therapeutic targets of autophagy in CCA have not been thoroughly studied. In this review, we introduce the classification, characteristics, process, and related regulatory genes of autophagy. We summarize the regulation of autophagy on the progression of CCA and collect the latest research progress on some autophagy modulators with clinical potential in CCA. In conclusion, combining autophagy modulators with immunotherapy, chemotherapy, and targeted therapy has great potential in the treatment of CCA. This combination may be a potential therapeutic target for CCA in the future.
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spelling pubmed-104772472023-09-06 The role and implication of autophagy in cholangiocarcinoma Khizar, Hayat Hu, Yufei Wu, Yanhua Yang, Jianfeng Cell Death Discov Review Article Cholangiocarcinoma (CCA) is a malignant tumor that originates from the biliary epithelial cells. It is characterized by a difficult diagnosis and limited treatment options. Autophagy is a cellular survival mechanism that maintains nutrient and energy homeostasis and eliminates intracellular pathogens. It is involved in various physiological and pathological processes, including the development of cancer. However, the role, mechanism, and potential therapeutic targets of autophagy in CCA have not been thoroughly studied. In this review, we introduce the classification, characteristics, process, and related regulatory genes of autophagy. We summarize the regulation of autophagy on the progression of CCA and collect the latest research progress on some autophagy modulators with clinical potential in CCA. In conclusion, combining autophagy modulators with immunotherapy, chemotherapy, and targeted therapy has great potential in the treatment of CCA. This combination may be a potential therapeutic target for CCA in the future. Nature Publishing Group UK 2023-09-04 /pmc/articles/PMC10477247/ /pubmed/37666811 http://dx.doi.org/10.1038/s41420-023-01631-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Khizar, Hayat
Hu, Yufei
Wu, Yanhua
Yang, Jianfeng
The role and implication of autophagy in cholangiocarcinoma
title The role and implication of autophagy in cholangiocarcinoma
title_full The role and implication of autophagy in cholangiocarcinoma
title_fullStr The role and implication of autophagy in cholangiocarcinoma
title_full_unstemmed The role and implication of autophagy in cholangiocarcinoma
title_short The role and implication of autophagy in cholangiocarcinoma
title_sort role and implication of autophagy in cholangiocarcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477247/
https://www.ncbi.nlm.nih.gov/pubmed/37666811
http://dx.doi.org/10.1038/s41420-023-01631-7
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