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Low‐affinity insulin‐like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival

Insulin‐like growth factor (IGF) binding proteins (IGFBPs) are a family of growth factor modifiers, some of which are known to be independently associated with pulmonary arterial hypertension (PAH) survival. IGF factor binding protein 7 (IGFBP7) is a unique low‐affinity IGFBP that, independent of IG...

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Autores principales: Torres, Guillermo, Lancaster, Andrew C., Yang, Jun, Griffiths, Megan, Brandal, Stephanie, Damico, Rachel, Vaidya, Dhananjay, Simpson, Catherine E., Martin, Lisa J., Pauciulo, Michael W., Nichols, William C., Ivy, David D., Austin, Eric D., Hassoun, Paul M., Everett, Allen D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477418/
https://www.ncbi.nlm.nih.gov/pubmed/37674873
http://dx.doi.org/10.1002/pul2.12284
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author Torres, Guillermo
Lancaster, Andrew C.
Yang, Jun
Griffiths, Megan
Brandal, Stephanie
Damico, Rachel
Vaidya, Dhananjay
Simpson, Catherine E.
Martin, Lisa J.
Pauciulo, Michael W.
Nichols, William C.
Ivy, David D.
Austin, Eric D.
Hassoun, Paul M.
Everett, Allen D.
author_facet Torres, Guillermo
Lancaster, Andrew C.
Yang, Jun
Griffiths, Megan
Brandal, Stephanie
Damico, Rachel
Vaidya, Dhananjay
Simpson, Catherine E.
Martin, Lisa J.
Pauciulo, Michael W.
Nichols, William C.
Ivy, David D.
Austin, Eric D.
Hassoun, Paul M.
Everett, Allen D.
author_sort Torres, Guillermo
collection PubMed
description Insulin‐like growth factor (IGF) binding proteins (IGFBPs) are a family of growth factor modifiers, some of which are known to be independently associated with pulmonary arterial hypertension (PAH) survival. IGF factor binding protein 7 (IGFBP7) is a unique low‐affinity IGFBP that, independent of IGF, stimulates prostacyclin production. This study proposed to establish associations between IGFBP7 and PAH severity and survival, using enrollment and longitudinal samples. Serum IGFBP7 levels were significantly elevated in patients with PAH compared to controls. After adjusting for age and sex, logarithmic increases in IGFBP7 were associated with a 20 m shorter six‐minute walk distance (6MWD; p < 0.001), a 2−3 mmHg higher mean right atrial pressure (p < 0.001 and 0.02), and a higher likelihood of a greater REVEAL 2.0 risk category placement (p < 0.001). Kaplan−Meier analysis demonstrated significantly decreased survival with IGFBP7 above the median and Cox multivariable analysis adjusted for age and sex, demonstrated higher serum IGFBP7 was an independent predictor of survival. Though the exact mechanism is still unknown, given IGFBP7's role as a prostacyclin stimulant, it has potential use as a therapeutic target for disease modulation.
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spelling pubmed-104774182023-09-06 Low‐affinity insulin‐like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival Torres, Guillermo Lancaster, Andrew C. Yang, Jun Griffiths, Megan Brandal, Stephanie Damico, Rachel Vaidya, Dhananjay Simpson, Catherine E. Martin, Lisa J. Pauciulo, Michael W. Nichols, William C. Ivy, David D. Austin, Eric D. Hassoun, Paul M. Everett, Allen D. Pulm Circ Research Articles Insulin‐like growth factor (IGF) binding proteins (IGFBPs) are a family of growth factor modifiers, some of which are known to be independently associated with pulmonary arterial hypertension (PAH) survival. IGF factor binding protein 7 (IGFBP7) is a unique low‐affinity IGFBP that, independent of IGF, stimulates prostacyclin production. This study proposed to establish associations between IGFBP7 and PAH severity and survival, using enrollment and longitudinal samples. Serum IGFBP7 levels were significantly elevated in patients with PAH compared to controls. After adjusting for age and sex, logarithmic increases in IGFBP7 were associated with a 20 m shorter six‐minute walk distance (6MWD; p < 0.001), a 2−3 mmHg higher mean right atrial pressure (p < 0.001 and 0.02), and a higher likelihood of a greater REVEAL 2.0 risk category placement (p < 0.001). Kaplan−Meier analysis demonstrated significantly decreased survival with IGFBP7 above the median and Cox multivariable analysis adjusted for age and sex, demonstrated higher serum IGFBP7 was an independent predictor of survival. Though the exact mechanism is still unknown, given IGFBP7's role as a prostacyclin stimulant, it has potential use as a therapeutic target for disease modulation. John Wiley and Sons Inc. 2023-09-04 /pmc/articles/PMC10477418/ /pubmed/37674873 http://dx.doi.org/10.1002/pul2.12284 Text en © 2023 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Torres, Guillermo
Lancaster, Andrew C.
Yang, Jun
Griffiths, Megan
Brandal, Stephanie
Damico, Rachel
Vaidya, Dhananjay
Simpson, Catherine E.
Martin, Lisa J.
Pauciulo, Michael W.
Nichols, William C.
Ivy, David D.
Austin, Eric D.
Hassoun, Paul M.
Everett, Allen D.
Low‐affinity insulin‐like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival
title Low‐affinity insulin‐like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival
title_full Low‐affinity insulin‐like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival
title_fullStr Low‐affinity insulin‐like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival
title_full_unstemmed Low‐affinity insulin‐like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival
title_short Low‐affinity insulin‐like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival
title_sort low‐affinity insulin‐like growth factor binding protein 7 and its association with pulmonary arterial hypertension severity and survival
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477418/
https://www.ncbi.nlm.nih.gov/pubmed/37674873
http://dx.doi.org/10.1002/pul2.12284
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