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Tumoral Densities of T-Cells and Mast Cells Are Associated With Recurrence in Early-Stage Lung Adenocarcinoma
INTRODUCTION: Lung cancer is the deadliest cancer in the United States and worldwide, and lung adenocarcinoma (LUAD) is the most prevalent histologic subtype in the United States. LUAD exhibits a wide range of aggressiveness and risk of recurrence, but the biological underpinnings of this behavior a...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477685/ https://www.ncbi.nlm.nih.gov/pubmed/37674811 http://dx.doi.org/10.1016/j.jtocrr.2023.100504 |
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author | Kammer, Michael N. Mori, Hidetoshi Rowe, Dianna J. Chen, Sheau-Chiann Vasiukov, Georgii Atwater, Thomas Senosain, Maria Fernanda Antic, Sanja Zou, Yong Chen, Heidi Peikert, Tobias Deppen, Steve Grogan, Eric L. Massion, Pierre P. Dubinett, Steve Lenburg, Marc Borowsky, Alexander Maldonado, Fabien |
author_facet | Kammer, Michael N. Mori, Hidetoshi Rowe, Dianna J. Chen, Sheau-Chiann Vasiukov, Georgii Atwater, Thomas Senosain, Maria Fernanda Antic, Sanja Zou, Yong Chen, Heidi Peikert, Tobias Deppen, Steve Grogan, Eric L. Massion, Pierre P. Dubinett, Steve Lenburg, Marc Borowsky, Alexander Maldonado, Fabien |
author_sort | Kammer, Michael N. |
collection | PubMed |
description | INTRODUCTION: Lung cancer is the deadliest cancer in the United States and worldwide, and lung adenocarcinoma (LUAD) is the most prevalent histologic subtype in the United States. LUAD exhibits a wide range of aggressiveness and risk of recurrence, but the biological underpinnings of this behavior are poorly understood. Past studies have focused on the biological characteristics of the tumor itself, but the ability of the immune response to contain tumor growth represents an alternative or complementary hypothesis. Emerging technologies enable us to investigate the spatial distribution of specific cell types within the tumor nest and characterize this immune response. This study aimed to investigate the association between immune cell density within the primary tumor and recurrence-free survival (RFS) in stage I and II LUAD. METHODS: This study is a prospective collection with retrospective evaluation. A total of 100 patients with surgically resected LUAD and at least 5-year follow-ups, including 69 stage I and 31 stages II tumors, were enrolled. Multiplexed immunohistochemistry panels for immune markers were used for measurement. RESULTS: Cox regression models adjusted for sex and EGFR mutation status revealed that the risk of recurrence was reduced by 50% for the unit of one interquartile range (IQR) change in the tumoral T-cell (adjusted hazard ratio per IQR increase = 0.50, 95% confidence interval: 0.27–0.93) and decreased by 64% in mast cell density (adjusted hazard ratio per IQR increase = 0.36, confidence interval: 0.15–0.84). The analyses were reported without the type I error correction for the multiple types of immune cell testing. CONCLUSIONS: Analysis of the density of immune cells within the tumor and surrounding stroma reveals an association between the density of T-cells and RFS and between mast cells and RFS in early-stage LUAD. This preliminary result is a limited study with a small sample size and a lack of an independent validation set. |
format | Online Article Text |
id | pubmed-10477685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-104776852023-09-06 Tumoral Densities of T-Cells and Mast Cells Are Associated With Recurrence in Early-Stage Lung Adenocarcinoma Kammer, Michael N. Mori, Hidetoshi Rowe, Dianna J. Chen, Sheau-Chiann Vasiukov, Georgii Atwater, Thomas Senosain, Maria Fernanda Antic, Sanja Zou, Yong Chen, Heidi Peikert, Tobias Deppen, Steve Grogan, Eric L. Massion, Pierre P. Dubinett, Steve Lenburg, Marc Borowsky, Alexander Maldonado, Fabien JTO Clin Res Rep Original Article INTRODUCTION: Lung cancer is the deadliest cancer in the United States and worldwide, and lung adenocarcinoma (LUAD) is the most prevalent histologic subtype in the United States. LUAD exhibits a wide range of aggressiveness and risk of recurrence, but the biological underpinnings of this behavior are poorly understood. Past studies have focused on the biological characteristics of the tumor itself, but the ability of the immune response to contain tumor growth represents an alternative or complementary hypothesis. Emerging technologies enable us to investigate the spatial distribution of specific cell types within the tumor nest and characterize this immune response. This study aimed to investigate the association between immune cell density within the primary tumor and recurrence-free survival (RFS) in stage I and II LUAD. METHODS: This study is a prospective collection with retrospective evaluation. A total of 100 patients with surgically resected LUAD and at least 5-year follow-ups, including 69 stage I and 31 stages II tumors, were enrolled. Multiplexed immunohistochemistry panels for immune markers were used for measurement. RESULTS: Cox regression models adjusted for sex and EGFR mutation status revealed that the risk of recurrence was reduced by 50% for the unit of one interquartile range (IQR) change in the tumoral T-cell (adjusted hazard ratio per IQR increase = 0.50, 95% confidence interval: 0.27–0.93) and decreased by 64% in mast cell density (adjusted hazard ratio per IQR increase = 0.36, confidence interval: 0.15–0.84). The analyses were reported without the type I error correction for the multiple types of immune cell testing. CONCLUSIONS: Analysis of the density of immune cells within the tumor and surrounding stroma reveals an association between the density of T-cells and RFS and between mast cells and RFS in early-stage LUAD. This preliminary result is a limited study with a small sample size and a lack of an independent validation set. Elsevier 2023-03-23 /pmc/articles/PMC10477685/ /pubmed/37674811 http://dx.doi.org/10.1016/j.jtocrr.2023.100504 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Kammer, Michael N. Mori, Hidetoshi Rowe, Dianna J. Chen, Sheau-Chiann Vasiukov, Georgii Atwater, Thomas Senosain, Maria Fernanda Antic, Sanja Zou, Yong Chen, Heidi Peikert, Tobias Deppen, Steve Grogan, Eric L. Massion, Pierre P. Dubinett, Steve Lenburg, Marc Borowsky, Alexander Maldonado, Fabien Tumoral Densities of T-Cells and Mast Cells Are Associated With Recurrence in Early-Stage Lung Adenocarcinoma |
title | Tumoral Densities of T-Cells and Mast Cells Are Associated With Recurrence in Early-Stage Lung Adenocarcinoma |
title_full | Tumoral Densities of T-Cells and Mast Cells Are Associated With Recurrence in Early-Stage Lung Adenocarcinoma |
title_fullStr | Tumoral Densities of T-Cells and Mast Cells Are Associated With Recurrence in Early-Stage Lung Adenocarcinoma |
title_full_unstemmed | Tumoral Densities of T-Cells and Mast Cells Are Associated With Recurrence in Early-Stage Lung Adenocarcinoma |
title_short | Tumoral Densities of T-Cells and Mast Cells Are Associated With Recurrence in Early-Stage Lung Adenocarcinoma |
title_sort | tumoral densities of t-cells and mast cells are associated with recurrence in early-stage lung adenocarcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477685/ https://www.ncbi.nlm.nih.gov/pubmed/37674811 http://dx.doi.org/10.1016/j.jtocrr.2023.100504 |
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