Alkaline intracellular pH (pHi) increases PI3K activity to promote mTORC1 and mTORC2 signaling and function during growth factor limitation

The conserved protein kinase mTOR (mechanistic target of rapamycin) responds to diverse environmental cues to control cell metabolism and promote cell growth, proliferation, and survival as part of two multiprotein complexes, mTOR complex 1 (mTORC1) and mTORC2. Our prior work demonstrated that an al...

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Detalles Bibliográficos
Autores principales: Kazyken, Dubek, Lentz, Stephen I., Wadley, Maxwell, Fingar, Diane C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477693/
https://www.ncbi.nlm.nih.gov/pubmed/37507012
http://dx.doi.org/10.1016/j.jbc.2023.105097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477693/
https://www.ncbi.nlm.nih.gov/pubmed/37507012
http://dx.doi.org/10.1016/j.jbc.2023.105097

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