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Early monocular deprivation reduces the capacity for neural plasticity in the cat visual system
Obstruction of vision to one eye during early postnatal development elicits neural modifications in the visual system that can last a lifetime. Research in rodents has revealed that an early and transient monocular deprivation (MD) can produce an enduring alteration to the framework of neural connec...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477708/ https://www.ncbi.nlm.nih.gov/pubmed/37675436 http://dx.doi.org/10.1093/texcom/tgad017 |
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author | Henneberry, Jonathon Mark Elgallad, Joseph Smith, Seth Duffy, Kevin R |
author_facet | Henneberry, Jonathon Mark Elgallad, Joseph Smith, Seth Duffy, Kevin R |
author_sort | Henneberry, Jonathon Mark |
collection | PubMed |
description | Obstruction of vision to one eye during early postnatal development elicits neural modifications in the visual system that can last a lifetime. Research in rodents has revealed that an early and transient monocular deprivation (MD) can produce an enduring alteration to the framework of neural connections within visual cortex. This lasting trace of early MD enables an enhanced effect of a second MD imposed on the same eye in adulthood. In the current study, we examined whether the modification of plasticity potential was bidirectional by assessing whether the effect of early and brief MD attenuated the impact of a subsequent MD when applied to the fellow eye. Results were clear in showing that animals with an early MD exhibited a smaller response to later visual deprivation of the fellow eye. Compared to controls, animals with a history of MD exhibited less atrophy of neurons, and a smaller loss of neurofilament labeling within the dorsal lateral geniculate nucleus. The shift in cortical ocular dominance elicited by MD was also smaller in animals with a prior MD. These results indicate that early MD elicits abiding and eye-specific neural modifications that can selectively alter plasticity potential in the visual system. |
format | Online Article Text |
id | pubmed-10477708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-104777082023-09-06 Early monocular deprivation reduces the capacity for neural plasticity in the cat visual system Henneberry, Jonathon Mark Elgallad, Joseph Smith, Seth Duffy, Kevin R Cereb Cortex Commun Original Article Obstruction of vision to one eye during early postnatal development elicits neural modifications in the visual system that can last a lifetime. Research in rodents has revealed that an early and transient monocular deprivation (MD) can produce an enduring alteration to the framework of neural connections within visual cortex. This lasting trace of early MD enables an enhanced effect of a second MD imposed on the same eye in adulthood. In the current study, we examined whether the modification of plasticity potential was bidirectional by assessing whether the effect of early and brief MD attenuated the impact of a subsequent MD when applied to the fellow eye. Results were clear in showing that animals with an early MD exhibited a smaller response to later visual deprivation of the fellow eye. Compared to controls, animals with a history of MD exhibited less atrophy of neurons, and a smaller loss of neurofilament labeling within the dorsal lateral geniculate nucleus. The shift in cortical ocular dominance elicited by MD was also smaller in animals with a prior MD. These results indicate that early MD elicits abiding and eye-specific neural modifications that can selectively alter plasticity potential in the visual system. Oxford University Press 2023-08-17 /pmc/articles/PMC10477708/ /pubmed/37675436 http://dx.doi.org/10.1093/texcom/tgad017 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Henneberry, Jonathon Mark Elgallad, Joseph Smith, Seth Duffy, Kevin R Early monocular deprivation reduces the capacity for neural plasticity in the cat visual system |
title | Early monocular deprivation reduces the capacity for neural plasticity in the cat visual system |
title_full | Early monocular deprivation reduces the capacity for neural plasticity in the cat visual system |
title_fullStr | Early monocular deprivation reduces the capacity for neural plasticity in the cat visual system |
title_full_unstemmed | Early monocular deprivation reduces the capacity for neural plasticity in the cat visual system |
title_short | Early monocular deprivation reduces the capacity for neural plasticity in the cat visual system |
title_sort | early monocular deprivation reduces the capacity for neural plasticity in the cat visual system |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477708/ https://www.ncbi.nlm.nih.gov/pubmed/37675436 http://dx.doi.org/10.1093/texcom/tgad017 |
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