Endogenous H3.3K27M derived peptide restricted to HLA-A∗02:01 is insufficient for immune-targeting in diffuse midline glioma

Diffuse midline glioma (DMG) is a childhood brain tumor with an extremely poor prognosis. Chimeric antigen receptor (CAR) T cell therapy has recently demonstrated some success in DMG, but there may a need to target multiple tumor-specific targets to avoid antigen escape. We developed a second-genera...

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Detalles Bibliográficos
Autores principales: Wang, Stacie S., Pandey, Kirti, Watson, Katherine A., Abbott, Rebecca C., Mifsud, Nicole A., Gracey, Fiona M., Ramarathinam, Sri H., Cross, Ryan S., Purcell, Anthony W., Jenkins, Misty R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477804/
https://www.ncbi.nlm.nih.gov/pubmed/37674626
http://dx.doi.org/10.1016/j.omto.2023.08.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477804/
https://www.ncbi.nlm.nih.gov/pubmed/37674626
http://dx.doi.org/10.1016/j.omto.2023.08.005

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