A Targeted Thorium-227 Conjugate Demonstrates Efficacy in Preclinical Models of Acquired Drug Resistance and Combination Potential with Chemotherapeutics and Antiangiogenic Therapies

Targeted alpha therapies (TAT) are an innovative class of therapies for cancer treatment. The unique mode-of-action of TATs is the induction of deleterious DNA double-strand breaks. Difficult-to-treat cancers, such as gynecologic cancers upregulating the chemoresistance P-glycoprotein (p-gp) and ove...

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Detalles Bibliográficos
Autores principales: Zitzmann-Kolbe, Sabine, Kristian, Alexander, Zopf, Dieter, Kamfenkel, Claudia, Politz, Oliver, Ellingsen, Christine, Hilbig, Jochen, Juul, Mark U., Fonslet, Jesper, Nielsen, Carsten H., Schatz, Christoph A., Bjerke, Roger M., Cuthbertson, Alan S., Mumberg, Dominik, Hagemann, Urs B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Large Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477831/
https://www.ncbi.nlm.nih.gov/pubmed/37365121
http://dx.doi.org/10.1158/1535-7163.MCT-22-0808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477831/
https://www.ncbi.nlm.nih.gov/pubmed/37365121
http://dx.doi.org/10.1158/1535-7163.MCT-22-0808

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