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Upregulation of Somatostatin Receptor Type 2 Improves (177)Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model

Pancreatic neuroendocrine tumors (PNET) express high levels of somatostatin receptor type 2 (SSTR2), a unique target for both tumor imaging and therapy. This surface expression is lost in metastatic high-grade PNETs, making patients ineligible for SSTR2-targeted (177) Lutetium (Lu)-DOTATATE peptide...

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Detalles Bibliográficos
Autores principales:	Sharma, Rupali, Earla, Bhargav, Baidoo, Kwamena E., Zeiger, Martha A., Madigan, James P., Escorcia, Freddy E., Sadowski, Samira M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Small Molecule Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477832/ https://www.ncbi.nlm.nih.gov/pubmed/37487000 http://dx.doi.org/10.1158/1535-7163.MCT-22-0798

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