CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis (Adv. Sci. 25/2023)

Circulating Pathogenic Factors Circulating pathogenic factor for FSGS development has long been searched. In article number 2301492, Ke Zen, Zhihong Liu, and co‐workers identify exosomal miR‐186‐5p from activated CD8 T cells as such circulating pathogenic factor that causes renal dysfunction. In spe...

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Detalles Bibliográficos
Autores principales: Xu, Xiaodong, Qu, Shuang, Zhang, Changming, Zhang, Mingchao, Qin, Weisong, Ren, Guisheng, Bao, Hao, Li, Limin, Zen, Ke, Liu, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477841/
http://dx.doi.org/10.1002/advs.202370171
Descripción
Sumario:Circulating Pathogenic Factors Circulating pathogenic factor for FSGS development has long been searched. In article number 2301492, Ke Zen, Zhihong Liu, and co‐workers identify exosomal miR‐186‐5p from activated CD8 T cells as such circulating pathogenic factor that causes renal dysfunction. In specific, miR‐186‐5p is enriched in exosomes of activated CD8 T cells and preferentially enters renal tubular cells where it directly binds endosomal TLR7/8 and initiates renal inflammation. [Image: see text]

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