CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis (Adv. Sci. 25/2023)

Circulating Pathogenic Factors Circulating pathogenic factor for FSGS development has long been searched. In article number 2301492, Ke Zen, Zhihong Liu, and co‐workers identify exosomal miR‐186‐5p from activated CD8 T cells as such circulating pathogenic factor that causes renal dysfunction. In spe...

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Autores principales: Xu, Xiaodong, Qu, Shuang, Zhang, Changming, Zhang, Mingchao, Qin, Weisong, Ren, Guisheng, Bao, Hao, Li, Limin, Zen, Ke, Liu, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477841/
http://dx.doi.org/10.1002/advs.202370171
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author Xu, Xiaodong
Qu, Shuang
Zhang, Changming
Zhang, Mingchao
Qin, Weisong
Ren, Guisheng
Bao, Hao
Li, Limin
Zen, Ke
Liu, Zhihong
author_facet Xu, Xiaodong
Qu, Shuang
Zhang, Changming
Zhang, Mingchao
Qin, Weisong
Ren, Guisheng
Bao, Hao
Li, Limin
Zen, Ke
Liu, Zhihong
author_sort Xu, Xiaodong
collection PubMed
description Circulating Pathogenic Factors Circulating pathogenic factor for FSGS development has long been searched. In article number 2301492, Ke Zen, Zhihong Liu, and co‐workers identify exosomal miR‐186‐5p from activated CD8 T cells as such circulating pathogenic factor that causes renal dysfunction. In specific, miR‐186‐5p is enriched in exosomes of activated CD8 T cells and preferentially enters renal tubular cells where it directly binds endosomal TLR7/8 and initiates renal inflammation. [Image: see text]
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spelling pubmed-104778412023-09-06 CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis (Adv. Sci. 25/2023) Xu, Xiaodong Qu, Shuang Zhang, Changming Zhang, Mingchao Qin, Weisong Ren, Guisheng Bao, Hao Li, Limin Zen, Ke Liu, Zhihong Adv Sci (Weinh) Frontispiece Circulating Pathogenic Factors Circulating pathogenic factor for FSGS development has long been searched. In article number 2301492, Ke Zen, Zhihong Liu, and co‐workers identify exosomal miR‐186‐5p from activated CD8 T cells as such circulating pathogenic factor that causes renal dysfunction. In specific, miR‐186‐5p is enriched in exosomes of activated CD8 T cells and preferentially enters renal tubular cells where it directly binds endosomal TLR7/8 and initiates renal inflammation. [Image: see text] John Wiley and Sons Inc. 2023-09-05 /pmc/articles/PMC10477841/ http://dx.doi.org/10.1002/advs.202370171 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Frontispiece
Xu, Xiaodong
Qu, Shuang
Zhang, Changming
Zhang, Mingchao
Qin, Weisong
Ren, Guisheng
Bao, Hao
Li, Limin
Zen, Ke
Liu, Zhihong
CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis (Adv. Sci. 25/2023)
title CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis (Adv. Sci. 25/2023)
title_full CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis (Adv. Sci. 25/2023)
title_fullStr CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis (Adv. Sci. 25/2023)
title_full_unstemmed CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis (Adv. Sci. 25/2023)
title_short CD8 T Cell‐Derived Exosomal miR‐186‐5p Elicits Renal Inflammation via Activating Tubular TLR7/8 Signal Axis (Adv. Sci. 25/2023)
title_sort cd8 t cell‐derived exosomal mir‐186‐5p elicits renal inflammation via activating tubular tlr7/8 signal axis (adv. sci. 25/2023)
topic Frontispiece
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477841/
http://dx.doi.org/10.1002/advs.202370171
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