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MnO(2) Nanoflower Integrated Optoelectronic Biointerfaces for Photostimulation of Neurons

Optoelectronic biointerfaces have gained significant interest for wireless and electrical control of neurons. Three–dimentional (3D) pseudocapacitive nanomaterials with large surface areas and interconnected porous structures have great potential for optoelectronic biointerfaces that can fulfill the...

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Autores principales: Kaya, Lokman, Karatum, Onuralp, Balamur, Rıdvan, Kaleli, Hümeyra Nur, Önal, Asım, Vanalakar, Sharadrao Anandrao, Hasanreisoğlu, Murat, Nizamoglu, Sedat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477844/
https://www.ncbi.nlm.nih.gov/pubmed/37386797
http://dx.doi.org/10.1002/advs.202301854
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author Kaya, Lokman
Karatum, Onuralp
Balamur, Rıdvan
Kaleli, Hümeyra Nur
Önal, Asım
Vanalakar, Sharadrao Anandrao
Hasanreisoğlu, Murat
Nizamoglu, Sedat
author_facet Kaya, Lokman
Karatum, Onuralp
Balamur, Rıdvan
Kaleli, Hümeyra Nur
Önal, Asım
Vanalakar, Sharadrao Anandrao
Hasanreisoğlu, Murat
Nizamoglu, Sedat
author_sort Kaya, Lokman
collection PubMed
description Optoelectronic biointerfaces have gained significant interest for wireless and electrical control of neurons. Three–dimentional (3D) pseudocapacitive nanomaterials with large surface areas and interconnected porous structures have great potential for optoelectronic biointerfaces that can fulfill the requirement of high electrode‐electrolyte capacitance to effectively transduce light into stimulating ionic currents. In this study, the integration of 3D manganese dioxide (MnO(2)) nanoflowers into flexible optoelectronic biointerfaces for safe and efficient photostimulation of neurons is demonstrated. MnO(2) nanoflowers are grown via chemical bath deposition on the return electrode, which has a MnO(2) seed layer deposited via cyclic voltammetry. They facilitate a high interfacial capacitance (larger than 10 mF cm(−2)) and photogenerated charge density (over 20 µC cm(−2)) under low light intensity (1 mW mm(−2)). MnO(2) nanoflowers induce safe capacitive currents with reversible Faradaic reactions and do not cause any toxicity on hippocampal neurons in vitro, making them a promising material for biointerfacing with electrogenic cells. Patch‐clamp electrophysiology is recorded in the whole‐cell configuration of hippocampal neurons, and the optoelectronic biointerfaces trigger repetitive and rapid firing of action potentials in response to light pulse trains. This study points out the potential of electrochemically‐deposited 3D pseudocapacitive nanomaterials as a robust building block for optoelectronic control of neurons.
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spelling pubmed-104778442023-09-06 MnO(2) Nanoflower Integrated Optoelectronic Biointerfaces for Photostimulation of Neurons Kaya, Lokman Karatum, Onuralp Balamur, Rıdvan Kaleli, Hümeyra Nur Önal, Asım Vanalakar, Sharadrao Anandrao Hasanreisoğlu, Murat Nizamoglu, Sedat Adv Sci (Weinh) Research Articles Optoelectronic biointerfaces have gained significant interest for wireless and electrical control of neurons. Three–dimentional (3D) pseudocapacitive nanomaterials with large surface areas and interconnected porous structures have great potential for optoelectronic biointerfaces that can fulfill the requirement of high electrode‐electrolyte capacitance to effectively transduce light into stimulating ionic currents. In this study, the integration of 3D manganese dioxide (MnO(2)) nanoflowers into flexible optoelectronic biointerfaces for safe and efficient photostimulation of neurons is demonstrated. MnO(2) nanoflowers are grown via chemical bath deposition on the return electrode, which has a MnO(2) seed layer deposited via cyclic voltammetry. They facilitate a high interfacial capacitance (larger than 10 mF cm(−2)) and photogenerated charge density (over 20 µC cm(−2)) under low light intensity (1 mW mm(−2)). MnO(2) nanoflowers induce safe capacitive currents with reversible Faradaic reactions and do not cause any toxicity on hippocampal neurons in vitro, making them a promising material for biointerfacing with electrogenic cells. Patch‐clamp electrophysiology is recorded in the whole‐cell configuration of hippocampal neurons, and the optoelectronic biointerfaces trigger repetitive and rapid firing of action potentials in response to light pulse trains. This study points out the potential of electrochemically‐deposited 3D pseudocapacitive nanomaterials as a robust building block for optoelectronic control of neurons. John Wiley and Sons Inc. 2023-06-29 /pmc/articles/PMC10477844/ /pubmed/37386797 http://dx.doi.org/10.1002/advs.202301854 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Kaya, Lokman
Karatum, Onuralp
Balamur, Rıdvan
Kaleli, Hümeyra Nur
Önal, Asım
Vanalakar, Sharadrao Anandrao
Hasanreisoğlu, Murat
Nizamoglu, Sedat
MnO(2) Nanoflower Integrated Optoelectronic Biointerfaces for Photostimulation of Neurons
title MnO(2) Nanoflower Integrated Optoelectronic Biointerfaces for Photostimulation of Neurons
title_full MnO(2) Nanoflower Integrated Optoelectronic Biointerfaces for Photostimulation of Neurons
title_fullStr MnO(2) Nanoflower Integrated Optoelectronic Biointerfaces for Photostimulation of Neurons
title_full_unstemmed MnO(2) Nanoflower Integrated Optoelectronic Biointerfaces for Photostimulation of Neurons
title_short MnO(2) Nanoflower Integrated Optoelectronic Biointerfaces for Photostimulation of Neurons
title_sort mno(2) nanoflower integrated optoelectronic biointerfaces for photostimulation of neurons
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477844/
https://www.ncbi.nlm.nih.gov/pubmed/37386797
http://dx.doi.org/10.1002/advs.202301854
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