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Multi‐Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management

Many hydrogel patches are developed to solve the pervasive and severe challenge of complex wound healing, while most of them still lack satisfactory controllability and comprehensive functionality. Herein, inspired by multiple creatures, including octopuses and snails, a novel muti‐functional hydrog...

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Autores principales: Li, Wenzhao, Yu, Yunru, Huang, Rongkang, Wang, Xiaocheng, Lai, Puxiang, Chen, Kai, Shang, Luoran, Zhao, Yuanjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477846/
https://www.ncbi.nlm.nih.gov/pubmed/37376818
http://dx.doi.org/10.1002/advs.202301479
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author Li, Wenzhao
Yu, Yunru
Huang, Rongkang
Wang, Xiaocheng
Lai, Puxiang
Chen, Kai
Shang, Luoran
Zhao, Yuanjin
author_facet Li, Wenzhao
Yu, Yunru
Huang, Rongkang
Wang, Xiaocheng
Lai, Puxiang
Chen, Kai
Shang, Luoran
Zhao, Yuanjin
author_sort Li, Wenzhao
collection PubMed
description Many hydrogel patches are developed to solve the pervasive and severe challenge of complex wound healing, while most of them still lack satisfactory controllability and comprehensive functionality. Herein, inspired by multiple creatures, including octopuses and snails, a novel muti‐functional hydrogel patch is presented with controlled adhesion, antibacterial, drug release features, and multiple monitoring functions for intelligent wound healing management. The patch with micro suction‐cup actuator array and a tensile backing layer is composed of tannin grafted gelatin, Ag‐tannin nanoparticles, polyacrylamide (PAAm) and poly(N‐isopropylacrylamide) (PNIPAm). In virtue of the photothermal gel‐sol transition of tannin grafted gelatin and Ag‐tannin nanoparticles, the patches exert a dual anti‐microbial effect and temperature‐sensitive snail mucus‐like features. In addition, as the “suction‐cups” consisting of thermal responsive PNIPAm can undergo a contract‐relax transformation, the medical patches can adhere to the objects reversibly and responsively, and release their loaded vascular endothelial growth factor (VEGF) controllably for wound healing. More attractively, benefiting from their fatigue resistance, self‐healing ability of the tensile double network hydrogel, and electrical conductivity of Ag‐tannin nanoparticles, the proposed patches can report multiple wound physiology parameters sensitively and continuously. Thus, it is believed that this multi‐bioinspired patch has immense potential for future wound healing management.
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spelling pubmed-104778462023-09-06 Multi‐Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management Li, Wenzhao Yu, Yunru Huang, Rongkang Wang, Xiaocheng Lai, Puxiang Chen, Kai Shang, Luoran Zhao, Yuanjin Adv Sci (Weinh) Research Articles Many hydrogel patches are developed to solve the pervasive and severe challenge of complex wound healing, while most of them still lack satisfactory controllability and comprehensive functionality. Herein, inspired by multiple creatures, including octopuses and snails, a novel muti‐functional hydrogel patch is presented with controlled adhesion, antibacterial, drug release features, and multiple monitoring functions for intelligent wound healing management. The patch with micro suction‐cup actuator array and a tensile backing layer is composed of tannin grafted gelatin, Ag‐tannin nanoparticles, polyacrylamide (PAAm) and poly(N‐isopropylacrylamide) (PNIPAm). In virtue of the photothermal gel‐sol transition of tannin grafted gelatin and Ag‐tannin nanoparticles, the patches exert a dual anti‐microbial effect and temperature‐sensitive snail mucus‐like features. In addition, as the “suction‐cups” consisting of thermal responsive PNIPAm can undergo a contract‐relax transformation, the medical patches can adhere to the objects reversibly and responsively, and release their loaded vascular endothelial growth factor (VEGF) controllably for wound healing. More attractively, benefiting from their fatigue resistance, self‐healing ability of the tensile double network hydrogel, and electrical conductivity of Ag‐tannin nanoparticles, the proposed patches can report multiple wound physiology parameters sensitively and continuously. Thus, it is believed that this multi‐bioinspired patch has immense potential for future wound healing management. John Wiley and Sons Inc. 2023-06-27 /pmc/articles/PMC10477846/ /pubmed/37376818 http://dx.doi.org/10.1002/advs.202301479 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Li, Wenzhao
Yu, Yunru
Huang, Rongkang
Wang, Xiaocheng
Lai, Puxiang
Chen, Kai
Shang, Luoran
Zhao, Yuanjin
Multi‐Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management
title Multi‐Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management
title_full Multi‐Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management
title_fullStr Multi‐Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management
title_full_unstemmed Multi‐Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management
title_short Multi‐Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management
title_sort multi‐bioinspired functional conductive hydrogel patches for wound healing management
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477846/
https://www.ncbi.nlm.nih.gov/pubmed/37376818
http://dx.doi.org/10.1002/advs.202301479
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