Adamantaniline Derivatives Target ATP5B to Inhibit Translation of Hypoxia Inducible Factor‐1α

Hypoxia inducible factor‐1α (HIF‐1α) plays a critical role in cellular adaptation to hypoxia and it is a potential therapeutic target for anti‐cancer drugs. Applying high‐throughput screening, here it is found that HI‐101, a small molecule containing an adamantaniline moiety, effectively reduces HIF...

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Detalles Bibliográficos
Autores principales: Li, Huiti, Liu, Yali, Xue, Zian, Zhang, Li, Ruan, Xiaoxue, Yang, Jintong, Fan, Zhongjiao, Zhao, Hongfang, Cao, Yu, Chen, Guoqiang, Xu, Ying, Zhou, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477886/
https://www.ncbi.nlm.nih.gov/pubmed/37401167
http://dx.doi.org/10.1002/advs.202301071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477886/
https://www.ncbi.nlm.nih.gov/pubmed/37401167
http://dx.doi.org/10.1002/advs.202301071

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