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Biogenic Imaging Contrast Agents
Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular level to individual level. The unique properties...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477908/ https://www.ncbi.nlm.nih.gov/pubmed/37401173 http://dx.doi.org/10.1002/advs.202207090 |
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author | Dan, Qing Jiang, Xinpeng Wang, Run Dai, Zhifei Sun, Desheng |
author_facet | Dan, Qing Jiang, Xinpeng Wang, Run Dai, Zhifei Sun, Desheng |
author_sort | Dan, Qing |
collection | PubMed |
description | Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular level to individual level. The unique properties of BICAs, including expression by cells as reporters and specific genetic modification, facilitate various in vitro and in vivo studies, such as quantification of gene expression, observation of protein interactions, visualization of cellular proliferation, monitoring of metabolism, and detection of dysfunctions. Furthermore, in human body, BICAs are remarkably helpful for disease diagnosis when the dysregulation of these agents occurs and can be detected through imaging techniques. There are various BICAs matched with a set of imaging techniques, including fluorescent proteins for fluorescence imaging, gas vesicles for ultrasound imaging, and ferritin for magnetic resonance imaging. In addition, bimodal and multimodal imaging can be realized through combining the functions of different BICAs, which helps overcome the limitations of monomodal imaging. In this review, the focus is on the properties, mechanisms, applications, and future directions of BICAs. |
format | Online Article Text |
id | pubmed-10477908 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104779082023-09-06 Biogenic Imaging Contrast Agents Dan, Qing Jiang, Xinpeng Wang, Run Dai, Zhifei Sun, Desheng Adv Sci (Weinh) Reviews Imaging contrast agents are widely investigated in preclinical and clinical studies, among which biogenic imaging contrast agents (BICAs) are developing rapidly and playing an increasingly important role in biomedical research ranging from subcellular level to individual level. The unique properties of BICAs, including expression by cells as reporters and specific genetic modification, facilitate various in vitro and in vivo studies, such as quantification of gene expression, observation of protein interactions, visualization of cellular proliferation, monitoring of metabolism, and detection of dysfunctions. Furthermore, in human body, BICAs are remarkably helpful for disease diagnosis when the dysregulation of these agents occurs and can be detected through imaging techniques. There are various BICAs matched with a set of imaging techniques, including fluorescent proteins for fluorescence imaging, gas vesicles for ultrasound imaging, and ferritin for magnetic resonance imaging. In addition, bimodal and multimodal imaging can be realized through combining the functions of different BICAs, which helps overcome the limitations of monomodal imaging. In this review, the focus is on the properties, mechanisms, applications, and future directions of BICAs. John Wiley and Sons Inc. 2023-07-03 /pmc/articles/PMC10477908/ /pubmed/37401173 http://dx.doi.org/10.1002/advs.202207090 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Dan, Qing Jiang, Xinpeng Wang, Run Dai, Zhifei Sun, Desheng Biogenic Imaging Contrast Agents |
title | Biogenic Imaging Contrast Agents |
title_full | Biogenic Imaging Contrast Agents |
title_fullStr | Biogenic Imaging Contrast Agents |
title_full_unstemmed | Biogenic Imaging Contrast Agents |
title_short | Biogenic Imaging Contrast Agents |
title_sort | biogenic imaging contrast agents |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477908/ https://www.ncbi.nlm.nih.gov/pubmed/37401173 http://dx.doi.org/10.1002/advs.202207090 |
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