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Translation of nanotechnology-based implants for orthopedic applications: current barriers and future perspective

The objective of bioimplant engineering is to develop biologically compatible materials for restoring, preserving, or altering damaged tissues and/or organ functions. The variety of substances used for orthopedic implant applications has been substantially influenced by modern material technology. T...

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Autores principales: Chen, Long, Zhou, Chao, Jiang, Chanyi, Huang, Xiaogang, Liu, Zunyong, Zhang, Hengjian, Liang, Wenqing, Zhao, Jiayi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478008/
https://www.ncbi.nlm.nih.gov/pubmed/37675405
http://dx.doi.org/10.3389/fbioe.2023.1206806
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author Chen, Long
Zhou, Chao
Jiang, Chanyi
Huang, Xiaogang
Liu, Zunyong
Zhang, Hengjian
Liang, Wenqing
Zhao, Jiayi
author_facet Chen, Long
Zhou, Chao
Jiang, Chanyi
Huang, Xiaogang
Liu, Zunyong
Zhang, Hengjian
Liang, Wenqing
Zhao, Jiayi
author_sort Chen, Long
collection PubMed
description The objective of bioimplant engineering is to develop biologically compatible materials for restoring, preserving, or altering damaged tissues and/or organ functions. The variety of substances used for orthopedic implant applications has been substantially influenced by modern material technology. Therefore, nanomaterials can mimic the surface properties of normal tissues, including surface chemistry, topography, energy, and wettability. Moreover, the new characteristics of nanomaterials promote their application in sustaining the progression of many tissues. The current review establishes a basis for nanotechnology-driven biomaterials by demonstrating the fundamental design problems that influence the success or failure of an orthopedic graft, cell adhesion, proliferation, antimicrobial/antibacterial activity, and differentiation. In this context, extensive research has been conducted on the nano-functionalization of biomaterial surfaces to enhance cell adhesion, differentiation, propagation, and implant population with potent antimicrobial activity. The possible nanomaterials applications (in terms of a functional nanocoating or a nanostructured surface) may resolve a variety of issues (such as bacterial adhesion and corrosion) associated with conventional metallic or non-metallic grafts, primarily for optimizing implant procedures. Future developments in orthopedic biomaterials, such as smart biomaterials, porous structures, and 3D implants, show promise for achieving the necessary characteristics and shape of a stimuli-responsive implant. Ultimately, the major barriers to the commercialization of nanotechnology-derived biomaterials are addressed to help overcome the limitations of current orthopedic biomaterials in terms of critical fundamental factors including cost of therapy, quality, pain relief, and implant life. Despite the recent success of nanotechnology, there are significant hurdles that must be overcome before nanomedicine may be applied to orthopedics. The objective of this review was to provide a thorough examination of recent advancements, their commercialization prospects, as well as the challenges and potential perspectives associated with them. This review aims to assist healthcare providers and researchers in extracting relevant data to develop translational research within the field. In addition, it will assist the readers in comprehending the scope and gaps of nanomedicine’s applicability in the orthopedics field.
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spelling pubmed-104780082023-09-06 Translation of nanotechnology-based implants for orthopedic applications: current barriers and future perspective Chen, Long Zhou, Chao Jiang, Chanyi Huang, Xiaogang Liu, Zunyong Zhang, Hengjian Liang, Wenqing Zhao, Jiayi Front Bioeng Biotechnol Bioengineering and Biotechnology The objective of bioimplant engineering is to develop biologically compatible materials for restoring, preserving, or altering damaged tissues and/or organ functions. The variety of substances used for orthopedic implant applications has been substantially influenced by modern material technology. Therefore, nanomaterials can mimic the surface properties of normal tissues, including surface chemistry, topography, energy, and wettability. Moreover, the new characteristics of nanomaterials promote their application in sustaining the progression of many tissues. The current review establishes a basis for nanotechnology-driven biomaterials by demonstrating the fundamental design problems that influence the success or failure of an orthopedic graft, cell adhesion, proliferation, antimicrobial/antibacterial activity, and differentiation. In this context, extensive research has been conducted on the nano-functionalization of biomaterial surfaces to enhance cell adhesion, differentiation, propagation, and implant population with potent antimicrobial activity. The possible nanomaterials applications (in terms of a functional nanocoating or a nanostructured surface) may resolve a variety of issues (such as bacterial adhesion and corrosion) associated with conventional metallic or non-metallic grafts, primarily for optimizing implant procedures. Future developments in orthopedic biomaterials, such as smart biomaterials, porous structures, and 3D implants, show promise for achieving the necessary characteristics and shape of a stimuli-responsive implant. Ultimately, the major barriers to the commercialization of nanotechnology-derived biomaterials are addressed to help overcome the limitations of current orthopedic biomaterials in terms of critical fundamental factors including cost of therapy, quality, pain relief, and implant life. Despite the recent success of nanotechnology, there are significant hurdles that must be overcome before nanomedicine may be applied to orthopedics. The objective of this review was to provide a thorough examination of recent advancements, their commercialization prospects, as well as the challenges and potential perspectives associated with them. This review aims to assist healthcare providers and researchers in extracting relevant data to develop translational research within the field. In addition, it will assist the readers in comprehending the scope and gaps of nanomedicine’s applicability in the orthopedics field. Frontiers Media S.A. 2023-08-22 /pmc/articles/PMC10478008/ /pubmed/37675405 http://dx.doi.org/10.3389/fbioe.2023.1206806 Text en Copyright © 2023 Chen, Zhou, Jiang, Huang, Liu, Zhang, Liang and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Chen, Long
Zhou, Chao
Jiang, Chanyi
Huang, Xiaogang
Liu, Zunyong
Zhang, Hengjian
Liang, Wenqing
Zhao, Jiayi
Translation of nanotechnology-based implants for orthopedic applications: current barriers and future perspective
title Translation of nanotechnology-based implants for orthopedic applications: current barriers and future perspective
title_full Translation of nanotechnology-based implants for orthopedic applications: current barriers and future perspective
title_fullStr Translation of nanotechnology-based implants for orthopedic applications: current barriers and future perspective
title_full_unstemmed Translation of nanotechnology-based implants for orthopedic applications: current barriers and future perspective
title_short Translation of nanotechnology-based implants for orthopedic applications: current barriers and future perspective
title_sort translation of nanotechnology-based implants for orthopedic applications: current barriers and future perspective
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478008/
https://www.ncbi.nlm.nih.gov/pubmed/37675405
http://dx.doi.org/10.3389/fbioe.2023.1206806
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