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Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet

Maternal microbiota forms the first infant gut microbial inoculum, and perinatal factors (diet and use of antibiotics during pregnancy) and/or neonatal factors, like intra partum antibiotics, gestational age and mode of delivery, may influence microbial colonization. After birth, when the principal...

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Autores principales: Suárez-Martínez, Clara, Santaella-Pascual, Marina, Yagüe-Guirao, Genoveva, Martínez-Graciá, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478010/
https://www.ncbi.nlm.nih.gov/pubmed/37675422
http://dx.doi.org/10.3389/fmicb.2023.1236254
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author Suárez-Martínez, Clara
Santaella-Pascual, Marina
Yagüe-Guirao, Genoveva
Martínez-Graciá, Carmen
author_facet Suárez-Martínez, Clara
Santaella-Pascual, Marina
Yagüe-Guirao, Genoveva
Martínez-Graciá, Carmen
author_sort Suárez-Martínez, Clara
collection PubMed
description Maternal microbiota forms the first infant gut microbial inoculum, and perinatal factors (diet and use of antibiotics during pregnancy) and/or neonatal factors, like intra partum antibiotics, gestational age and mode of delivery, may influence microbial colonization. After birth, when the principal colonization occurs, the microbial diversity increases and converges toward a stable adult-like microbiota by the end of the first 3–5 years of life. However, during the early life, gut microbiota can be disrupted by other postnatal factors like mode of infant feeding, antibiotic usage, and various environmental factors generating a state of dysbiosis. Gut dysbiosis have been reported to increase the risk of necrotizing enterocolitis and some chronic diseases later in life, such as obesity, diabetes, cancer, allergies, and asthma. Therefore, understanding the impact of a correct maternal-to-infant microbial transfer and a good infant early colonization and maturation throughout life would reduce the risk of disease in early and late life. This paper reviews the published evidence on early-life gut microbiota development, as well as the different factors influencing its evolution before, at, and after birth, focusing on diet and nutrition during pregnancy and in the first months of life.
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spelling pubmed-104780102023-09-06 Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet Suárez-Martínez, Clara Santaella-Pascual, Marina Yagüe-Guirao, Genoveva Martínez-Graciá, Carmen Front Microbiol Microbiology Maternal microbiota forms the first infant gut microbial inoculum, and perinatal factors (diet and use of antibiotics during pregnancy) and/or neonatal factors, like intra partum antibiotics, gestational age and mode of delivery, may influence microbial colonization. After birth, when the principal colonization occurs, the microbial diversity increases and converges toward a stable adult-like microbiota by the end of the first 3–5 years of life. However, during the early life, gut microbiota can be disrupted by other postnatal factors like mode of infant feeding, antibiotic usage, and various environmental factors generating a state of dysbiosis. Gut dysbiosis have been reported to increase the risk of necrotizing enterocolitis and some chronic diseases later in life, such as obesity, diabetes, cancer, allergies, and asthma. Therefore, understanding the impact of a correct maternal-to-infant microbial transfer and a good infant early colonization and maturation throughout life would reduce the risk of disease in early and late life. This paper reviews the published evidence on early-life gut microbiota development, as well as the different factors influencing its evolution before, at, and after birth, focusing on diet and nutrition during pregnancy and in the first months of life. Frontiers Media S.A. 2023-08-22 /pmc/articles/PMC10478010/ /pubmed/37675422 http://dx.doi.org/10.3389/fmicb.2023.1236254 Text en Copyright © 2023 Suárez-Martínez, Santaella-Pascual, Yagüe-Guirao and Martínez-Graciá. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Suárez-Martínez, Clara
Santaella-Pascual, Marina
Yagüe-Guirao, Genoveva
Martínez-Graciá, Carmen
Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet
title Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet
title_full Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet
title_fullStr Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet
title_full_unstemmed Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet
title_short Infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet
title_sort infant gut microbiota colonization: influence of prenatal and postnatal factors, focusing on diet
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478010/
https://www.ncbi.nlm.nih.gov/pubmed/37675422
http://dx.doi.org/10.3389/fmicb.2023.1236254
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