Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326)

INTRODUCTION: Syphilis, a sexually transmitted infection caused by the spirochete Treponema pallidum (Tp), is resurging globally. Tp’s repertoire of outer membrane proteins (OMPs) includes BamA (β-barrel assembly machinery subunit A/TP0326), a bipartite protein consisting of a 16-stranded β-barrel w...

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Detalles Bibliográficos
Autores principales: Ferguson, Mary R., Delgado, Kristina N., McBride, Shannon, Orbe, Isabel C., La Vake, Carson J., Caimano, Melissa J., Mendez, Qiana, Moraes, Trevor F., Schryvers, Anthony B., Moody, M. Anthony, Radolf, Justin D., Weiner, Michael P., Hawley, Kelly L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478084/
https://www.ncbi.nlm.nih.gov/pubmed/37675118
http://dx.doi.org/10.3389/fimmu.2023.1222267

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