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KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK cell antitumor activity against solid tumors

INTRODUCTION: Natural Killer (NK) cells hold the potential to shift cell therapy from a complex autologous option to a universal off-the-shelf one. Although NK cells have demonstrated efficacy and safety in the treatment of leukemia, the limited efficacy of NK cell-based immunotherapies against soli...

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Detalles Bibliográficos
Autores principales:	Mac Donald, Alice, Guipouy, Delphine, Lemieux, William, Harvey, Mario, Bordeleau, Louis-Jean, Guay, David, Roméro, Hugo, Li, Yuanyi, Dion, Renaud, Béland, Kathie, Haddad, Elie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478211/ https://www.ncbi.nlm.nih.gov/pubmed/37675109 http://dx.doi.org/10.3389/fimmu.2023.1231916

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