Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages

BACKGROUND: Intervertebral disc degeneration (IVDD) is a major contributor to spinal disorders. Previous studies have indicated that the infiltration of immunocytes, specifically macrophages, plays a crucial role in the advancement of IVDD. Exosomes (exo) are believed to play a significant role in i...

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Detalles Bibliográficos
Autores principales: Zhao, Xin, Sun, Zhen, Xu, Benchi, Duan, Wei, Chang, Le, Lai, Kangwei, Ye, Zhengxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478255/
https://www.ncbi.nlm.nih.gov/pubmed/37667246
http://dx.doi.org/10.1186/s12951-023-02075-y

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