Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis

Ulcerative colitis (UC) is a refractory inflammatory bowel disease, and the outcomes of conventional therapies of UC, including 5-aminosalicylic acid, glucocorticoids, immunosuppressants, and biological agents, are not satisfied with patients and physicians with regard to adverse reactions and finan...

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Autores principales: Shan, Jingyi, Liu, Suxian, Liu, Haoyue, Yuan, Jianye, Lin, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478270/
https://www.ncbi.nlm.nih.gov/pubmed/37675045
http://dx.doi.org/10.3389/fphar.2023.1221849
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author Shan, Jingyi
Liu, Suxian
Liu, Haoyue
Yuan, Jianye
Lin, Jiang
author_facet Shan, Jingyi
Liu, Suxian
Liu, Haoyue
Yuan, Jianye
Lin, Jiang
author_sort Shan, Jingyi
collection PubMed
description Ulcerative colitis (UC) is a refractory inflammatory bowel disease, and the outcomes of conventional therapies of UC, including 5-aminosalicylic acid, glucocorticoids, immunosuppressants, and biological agents, are not satisfied with patients and physicians with regard to adverse reactions and financial burden. The abnormality of the intestinal mucosal barrier in the pathogenesis of UC was verified. Qingchang Suppository (QCS) is an herbal preparation and is effective in treating ulcerative proctitis. The mechanism of QCS and its active ingredients have not been concluded especially in mucosal healing. This review elucidated the potential mechanism of QCS from the intestinal mucosal barrier perspective to help exploring future QCS research directions.
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spelling pubmed-104782702023-09-06 Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis Shan, Jingyi Liu, Suxian Liu, Haoyue Yuan, Jianye Lin, Jiang Front Pharmacol Pharmacology Ulcerative colitis (UC) is a refractory inflammatory bowel disease, and the outcomes of conventional therapies of UC, including 5-aminosalicylic acid, glucocorticoids, immunosuppressants, and biological agents, are not satisfied with patients and physicians with regard to adverse reactions and financial burden. The abnormality of the intestinal mucosal barrier in the pathogenesis of UC was verified. Qingchang Suppository (QCS) is an herbal preparation and is effective in treating ulcerative proctitis. The mechanism of QCS and its active ingredients have not been concluded especially in mucosal healing. This review elucidated the potential mechanism of QCS from the intestinal mucosal barrier perspective to help exploring future QCS research directions. Frontiers Media S.A. 2023-08-22 /pmc/articles/PMC10478270/ /pubmed/37675045 http://dx.doi.org/10.3389/fphar.2023.1221849 Text en Copyright © 2023 Shan, Liu, Liu, Yuan and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Shan, Jingyi
Liu, Suxian
Liu, Haoyue
Yuan, Jianye
Lin, Jiang
Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis
title Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis
title_full Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis
title_fullStr Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis
title_full_unstemmed Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis
title_short Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis
title_sort mechanism of qingchang suppository on repairing the intestinal mucosal barrier in ulcerative colitis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478270/
https://www.ncbi.nlm.nih.gov/pubmed/37675045
http://dx.doi.org/10.3389/fphar.2023.1221849
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