RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia

BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common pediatric hematological malignancy, with ETV6::RUNX1 being the most prevalent translocation whose exact pathogenesis remains unclear. IGF2BP1 (Insulin-like Growth Factor 2 Binding Protein 1) is an oncofetal RNA binding protein seen to...

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Detalles Bibliográficos
Autores principales: Sharma, Gunjan, Tran, Tiffany M., Bansal, Ishu, Beg, Mohammad Sabique, Bhardwaj, Ruchi, Bassi, Jaspal, Tan, Yuande, Jaiswal, Amit Kumar, Tso, Christine, Jain, Ayushi, Singh, Jay, Chattopadhyay, Parthaprasad, Singh, Archna, Chopra, Anita, Bakhshi, Sameer, Casero, David, Rao, Dinesh S., Palanichamy, Jayanth Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478443/
https://www.ncbi.nlm.nih.gov/pubmed/37670323
http://dx.doi.org/10.1186/s13046-023-02810-1

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