Beyond rational—biosensor-guided isolation of 100 independently evolved bacterial strain variants and comparative analysis of their genomes

BACKGROUND: In contrast to modern rational metabolic engineering, classical strain development strongly relies on random mutagenesis and screening for the desired production phenotype. Nowadays, with the availability of biosensor-based FACS screening strategies, these random approaches are coming ba...

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Detalles Bibliográficos
Autores principales: Baumann, Philipp T., Dal Molin, Michael, Aring, Hannah, Krumbach, Karin, Müller, Moritz-Fabian, Vroling, Bas, van Summeren-Wesenhagen, Philana V., Noack, Stephan, Marienhagen, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478468/
https://www.ncbi.nlm.nih.gov/pubmed/37667306
http://dx.doi.org/10.1186/s12915-023-01688-x

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