Cutaneous presentation of cryptococcal infection with subclinical central nervous system involvement secondary to fingolimod therapy

Fingolimod is a multiple sclerosis disease-modifying therapy which sequestrates lymphocytes in the lymph nodes, thereby reducing peripheral blood lymphocytes. Cryptococcal infection is an important adverse effect which should be recognised. We report a case of cutaneous and central nervous system in...

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Autores principales: Chey, Shin Yee, O’Sullivan, Niamh-Anna, Beer, Trevor, Leong, Wai K, Kermode, Allan G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478555/
https://www.ncbi.nlm.nih.gov/pubmed/37674981
http://dx.doi.org/10.1177/20552173231197132
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author Chey, Shin Yee
O’Sullivan, Niamh-Anna
Beer, Trevor
Leong, Wai K
Kermode, Allan G
author_facet Chey, Shin Yee
O’Sullivan, Niamh-Anna
Beer, Trevor
Leong, Wai K
Kermode, Allan G
author_sort Chey, Shin Yee
collection PubMed
description Fingolimod is a multiple sclerosis disease-modifying therapy which sequestrates lymphocytes in the lymph nodes, thereby reducing peripheral blood lymphocytes. Cryptococcal infection is an important adverse effect which should be recognised. We report a case of cutaneous and central nervous system infection who presented with isolated cutaneous symptoms in the absence of neurological or systemic manifestations.
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spelling pubmed-104785552023-09-06 Cutaneous presentation of cryptococcal infection with subclinical central nervous system involvement secondary to fingolimod therapy Chey, Shin Yee O’Sullivan, Niamh-Anna Beer, Trevor Leong, Wai K Kermode, Allan G Mult Scler J Exp Transl Clin Case Report Fingolimod is a multiple sclerosis disease-modifying therapy which sequestrates lymphocytes in the lymph nodes, thereby reducing peripheral blood lymphocytes. Cryptococcal infection is an important adverse effect which should be recognised. We report a case of cutaneous and central nervous system infection who presented with isolated cutaneous symptoms in the absence of neurological or systemic manifestations. SAGE Publications 2023-09-03 /pmc/articles/PMC10478555/ /pubmed/37674981 http://dx.doi.org/10.1177/20552173231197132 Text en © The Author(s), 2023 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Chey, Shin Yee
O’Sullivan, Niamh-Anna
Beer, Trevor
Leong, Wai K
Kermode, Allan G
Cutaneous presentation of cryptococcal infection with subclinical central nervous system involvement secondary to fingolimod therapy
title Cutaneous presentation of cryptococcal infection with subclinical central nervous system involvement secondary to fingolimod therapy
title_full Cutaneous presentation of cryptococcal infection with subclinical central nervous system involvement secondary to fingolimod therapy
title_fullStr Cutaneous presentation of cryptococcal infection with subclinical central nervous system involvement secondary to fingolimod therapy
title_full_unstemmed Cutaneous presentation of cryptococcal infection with subclinical central nervous system involvement secondary to fingolimod therapy
title_short Cutaneous presentation of cryptococcal infection with subclinical central nervous system involvement secondary to fingolimod therapy
title_sort cutaneous presentation of cryptococcal infection with subclinical central nervous system involvement secondary to fingolimod therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478555/
https://www.ncbi.nlm.nih.gov/pubmed/37674981
http://dx.doi.org/10.1177/20552173231197132
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