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Novel starting points for fragment-based drug design against mycobacterial thioredoxin reductase identified using crystallographic fragment screening

The increasing number of people dying from tuberculosis and the existence of extensively drug-resistant strains has led to an urgent need for new antituberculotic drugs with alternative modes of action. As part of the thioredoxin system, thioredoxin reductase (TrxR) is essential for the survival of...

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Detalles Bibliográficos
Autores principales: Füsser, Friederike T., Wollenhaupt, Jan, Weiss, Manfred S., Kümmel, Daniel, Koch, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478635/
https://www.ncbi.nlm.nih.gov/pubmed/37574972
http://dx.doi.org/10.1107/S2059798323005223

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