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Structural basis of the amidase ClbL central to the biosynthesis of the genotoxin colibactin

Colibactin is a genotoxic natural product produced by select commensal bacteria in the human gut microbiota. The compound is a bis-electrophile that is predicted to form interstrand DNA cross-links in target cells, leading to double-strand DNA breaks. The biosynthesis of colibactin is carried out by...

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Detalles Bibliográficos
Autores principales:	Tripathi, Prabhanshu, Mousa, Jarrod J., Guntaka, Naga Sandhya, Bruner, Steven D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2023
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478638/ https://www.ncbi.nlm.nih.gov/pubmed/37561403 http://dx.doi.org/10.1107/S2059798323005703

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