Determinants of Childhood Asthma: A Case Control Study from a Tertiary Care Hospital in Bengaluru, South India

BACKGROUND: Childhood asthma is a common, and often serious, chronic disease with episodic exacerbations in infants and children. There is an increasing trend in the prevalence of childhood asthma in developing countries. Objectives: To identify the determinants of childhood asthma. METHODS: A case control study with 30 cases of childhood asthma and 30 gender- and aged-matched controls selected from the paediatric outpatient department and paediatric ward of a tertiary hospital. The primary caregiver was interviewed to capture sociodemographic details, prenatal and birth history, and history of exposure to environmental risk factors. Odds ratios with 95% confidence intervals were calculated to determine the strength of association between childhood asthma and independent co-variates, followed by subgroup multiple logistic regression analysis. RESULTS: We found that children with a parental history of allergy/atopy [OR=2.88 (1.94–4.27), P<0.001], residence in houses located in industrial areas [AOR=2.72 (2.6–323.1), P<0.001], exposure to incense at home [AOR=2.03 (1.14–29.42), P<0.001], or a history of allergic rhinitis [AOR=3.09 (2.22–243.25), P<0.001] had significantly higher odds of developing childhood asthma. CONCLUSION: Our study found that having homes located in industrial areas, burning incense at home, parental history of allergy, and history of allergic rhinitis in the child are determinants of childhood asthma. The findings from our study can be used to generate awareness regarding risk factors that are linked to childhood asthma.