Cargando…
The impact of maternal electrolyte and albumin levels on the efficacy of single-dose methotrexate treatment for ectopic pregnancies
OBJECTIVE: This study aims to investigate the impact of maternal albumin and serum electrolyte levels on the efficacy of single-dose methotrexate (SDMtx) therapy for ectopic pregnancies. Building on previous research, recommendations are provided to enhance the success of SD-Mtx therapy in the manag...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478729/ https://www.ncbi.nlm.nih.gov/pubmed/37667559 http://dx.doi.org/10.4274/tjod.galenos.2023.71509 |
_version_ | 1785101413951471616 |
---|---|
author | Başkıran, Yusuf Uçkan, Kazım Karaçor, Talip Çeleğen, İzzet Acar, Züat |
author_facet | Başkıran, Yusuf Uçkan, Kazım Karaçor, Talip Çeleğen, İzzet Acar, Züat |
author_sort | Başkıran, Yusuf |
collection | PubMed |
description | OBJECTIVE: This study aims to investigate the impact of maternal albumin and serum electrolyte levels on the efficacy of single-dose methotrexate (SDMtx) therapy for ectopic pregnancies. Building on previous research, recommendations are provided to enhance the success of SD-Mtx therapy in the management of ectopic pregnancy. MATERIALS AND METHODS: Conducted at a tertiary center gynecology clinic, the study included 353 patients diagnosed with ectopic pregnancy and treated with SD-Mtx from 2012 to 2023. Patients who responded positively to SD-Mtx treatment comprised Group 1 (n=313), while those requiring surgical intervention due to failed SD-Mtx therapy constituted Group 2 (n=40). Through the hospital’s digital database, patient data including complete blood count, biochemistry, and hormone test results were retrospectively examined. RESULTS: The mean β-hCG value was 1996 IU/mL for Group 1 in contrast to 2058 IU/mL for Group 2. There was no statistically significant difference in β-hCG levels between the two groups. Notably, Group 1 patients exhibited lower serum magnesium levels but higher potassium levels compared to Group 2 patients, with statistically significant differences. Furthermore, Group 1 patients had higher albumin levels than those in Group 2, with a statistically significant difference. CONCLUSION: Successful SD-Mtx treatment was associated with lower maternal serum magnesium levels and higher potassium and albumin levels. Considering electrolyte levels before administering SD-Mtx and addressing any imbalances could potentially enhance treatment success. Additionally, restoring low albumin levels might improve the efficacy of SD-Mtx treatment for ectopic pregnancies. While this study suggests these trends, further extensive studies with a larger sample size are necessary to establish more definitive evidence. |
format | Online Article Text |
id | pubmed-10478729 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-104787292023-09-06 The impact of maternal electrolyte and albumin levels on the efficacy of single-dose methotrexate treatment for ectopic pregnancies Başkıran, Yusuf Uçkan, Kazım Karaçor, Talip Çeleğen, İzzet Acar, Züat Turk J Obstet Gynecol Clinical Investigation OBJECTIVE: This study aims to investigate the impact of maternal albumin and serum electrolyte levels on the efficacy of single-dose methotrexate (SDMtx) therapy for ectopic pregnancies. Building on previous research, recommendations are provided to enhance the success of SD-Mtx therapy in the management of ectopic pregnancy. MATERIALS AND METHODS: Conducted at a tertiary center gynecology clinic, the study included 353 patients diagnosed with ectopic pregnancy and treated with SD-Mtx from 2012 to 2023. Patients who responded positively to SD-Mtx treatment comprised Group 1 (n=313), while those requiring surgical intervention due to failed SD-Mtx therapy constituted Group 2 (n=40). Through the hospital’s digital database, patient data including complete blood count, biochemistry, and hormone test results were retrospectively examined. RESULTS: The mean β-hCG value was 1996 IU/mL for Group 1 in contrast to 2058 IU/mL for Group 2. There was no statistically significant difference in β-hCG levels between the two groups. Notably, Group 1 patients exhibited lower serum magnesium levels but higher potassium levels compared to Group 2 patients, with statistically significant differences. Furthermore, Group 1 patients had higher albumin levels than those in Group 2, with a statistically significant difference. CONCLUSION: Successful SD-Mtx treatment was associated with lower maternal serum magnesium levels and higher potassium and albumin levels. Considering electrolyte levels before administering SD-Mtx and addressing any imbalances could potentially enhance treatment success. Additionally, restoring low albumin levels might improve the efficacy of SD-Mtx treatment for ectopic pregnancies. While this study suggests these trends, further extensive studies with a larger sample size are necessary to establish more definitive evidence. Galenos Publishing 2023-09 2023-09-04 /pmc/articles/PMC10478729/ /pubmed/37667559 http://dx.doi.org/10.4274/tjod.galenos.2023.71509 Text en ©Copyright 2023 by Turkish Society of Obstetrics and Gynecology | Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Investigation Başkıran, Yusuf Uçkan, Kazım Karaçor, Talip Çeleğen, İzzet Acar, Züat The impact of maternal electrolyte and albumin levels on the efficacy of single-dose methotrexate treatment for ectopic pregnancies |
title | The impact of maternal electrolyte and albumin levels on the efficacy of single-dose methotrexate treatment for ectopic pregnancies |
title_full | The impact of maternal electrolyte and albumin levels on the efficacy of single-dose methotrexate treatment for ectopic pregnancies |
title_fullStr | The impact of maternal electrolyte and albumin levels on the efficacy of single-dose methotrexate treatment for ectopic pregnancies |
title_full_unstemmed | The impact of maternal electrolyte and albumin levels on the efficacy of single-dose methotrexate treatment for ectopic pregnancies |
title_short | The impact of maternal electrolyte and albumin levels on the efficacy of single-dose methotrexate treatment for ectopic pregnancies |
title_sort | impact of maternal electrolyte and albumin levels on the efficacy of single-dose methotrexate treatment for ectopic pregnancies |
topic | Clinical Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478729/ https://www.ncbi.nlm.nih.gov/pubmed/37667559 http://dx.doi.org/10.4274/tjod.galenos.2023.71509 |
work_keys_str_mv | AT baskıranyusuf theimpactofmaternalelectrolyteandalbuminlevelsontheefficacyofsingledosemethotrexatetreatmentforectopicpregnancies AT uckankazım theimpactofmaternalelectrolyteandalbuminlevelsontheefficacyofsingledosemethotrexatetreatmentforectopicpregnancies AT karacortalip theimpactofmaternalelectrolyteandalbuminlevelsontheefficacyofsingledosemethotrexatetreatmentforectopicpregnancies AT celegenizzet theimpactofmaternalelectrolyteandalbuminlevelsontheefficacyofsingledosemethotrexatetreatmentforectopicpregnancies AT acarzuat theimpactofmaternalelectrolyteandalbuminlevelsontheefficacyofsingledosemethotrexatetreatmentforectopicpregnancies AT baskıranyusuf impactofmaternalelectrolyteandalbuminlevelsontheefficacyofsingledosemethotrexatetreatmentforectopicpregnancies AT uckankazım impactofmaternalelectrolyteandalbuminlevelsontheefficacyofsingledosemethotrexatetreatmentforectopicpregnancies AT karacortalip impactofmaternalelectrolyteandalbuminlevelsontheefficacyofsingledosemethotrexatetreatmentforectopicpregnancies AT celegenizzet impactofmaternalelectrolyteandalbuminlevelsontheefficacyofsingledosemethotrexatetreatmentforectopicpregnancies AT acarzuat impactofmaternalelectrolyteandalbuminlevelsontheefficacyofsingledosemethotrexatetreatmentforectopicpregnancies |