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Persistent delusional disorder: psychopathological remission associated with clozapine-induced epileptic seizures

INTRODUCTION: Persistent delusional disorder has some features similar to schizophrenia, although the functionality of patients with this diagnosis is usually higher and is diagnosed at an older age. Although the pharmacological treatment of schizophrenia has been studied extensively, there is not m...

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Autores principales: Felizardo, M., Freitas, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479170/
http://dx.doi.org/10.1192/j.eurpsy.2023.2286
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author Felizardo, M.
Freitas, C.
author_facet Felizardo, M.
Freitas, C.
author_sort Felizardo, M.
collection PubMed
description INTRODUCTION: Persistent delusional disorder has some features similar to schizophrenia, although the functionality of patients with this diagnosis is usually higher and is diagnosed at an older age. Although the pharmacological treatment of schizophrenia has been studied extensively, there is not much data on the treatment of persistent delusional disorder. Regarding the use of clozapines specifically in persistent delusional disorders, there are some case reports with encouraging results. Electroconvulsive therapy is not generally used as a treatment for persistent delusional disorder. OBJECTIVES: To reflect on the relevance of using electronvulsive therapy in the treatment of persistent delusional disorder. METHODS: Through the description of a clinical case in which there was evidence of remission of resistant psychotic symptoms after clozapine-induced epileptic seizures, the authors hypothesize the existence of a direct relationship between the crisis and the resolution of a persistent delusional disorder. RESULTS: A.F., 78 years old, male. No personal history of psychiatric or medical-surgical illness. Admitted for psychotic decompensation framed in persistent delusional disorder. The patient underwent pharmacological treatment with resistance to three lines of antipsychotics. With the introduction of clozapine 100mg/day, the patient had two epileptic seizures, followed by complete remission of psychotic symptoms. CONCLUSIONS: The clinical case described refers to a patient diagnosed with resistant persistent delusional disorder, with almost immediate resolution of the condition after epileptic seizures induced by clozapine. Taking into account the clinical response in our patient to two spontaneous epileptic seizures, we hypothesize that electroconvulsive therapy may be effective in the treatment of persistent delusional disorder. DISCLOSURE OF INTEREST: None Declared
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spelling pubmed-104791702023-09-06 Persistent delusional disorder: psychopathological remission associated with clozapine-induced epileptic seizures Felizardo, M. Freitas, C. Eur Psychiatry Abstract INTRODUCTION: Persistent delusional disorder has some features similar to schizophrenia, although the functionality of patients with this diagnosis is usually higher and is diagnosed at an older age. Although the pharmacological treatment of schizophrenia has been studied extensively, there is not much data on the treatment of persistent delusional disorder. Regarding the use of clozapines specifically in persistent delusional disorders, there are some case reports with encouraging results. Electroconvulsive therapy is not generally used as a treatment for persistent delusional disorder. OBJECTIVES: To reflect on the relevance of using electronvulsive therapy in the treatment of persistent delusional disorder. METHODS: Through the description of a clinical case in which there was evidence of remission of resistant psychotic symptoms after clozapine-induced epileptic seizures, the authors hypothesize the existence of a direct relationship between the crisis and the resolution of a persistent delusional disorder. RESULTS: A.F., 78 years old, male. No personal history of psychiatric or medical-surgical illness. Admitted for psychotic decompensation framed in persistent delusional disorder. The patient underwent pharmacological treatment with resistance to three lines of antipsychotics. With the introduction of clozapine 100mg/day, the patient had two epileptic seizures, followed by complete remission of psychotic symptoms. CONCLUSIONS: The clinical case described refers to a patient diagnosed with resistant persistent delusional disorder, with almost immediate resolution of the condition after epileptic seizures induced by clozapine. Taking into account the clinical response in our patient to two spontaneous epileptic seizures, we hypothesize that electroconvulsive therapy may be effective in the treatment of persistent delusional disorder. DISCLOSURE OF INTEREST: None Declared Cambridge University Press 2023-07-19 /pmc/articles/PMC10479170/ http://dx.doi.org/10.1192/j.eurpsy.2023.2286 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Felizardo, M.
Freitas, C.
Persistent delusional disorder: psychopathological remission associated with clozapine-induced epileptic seizures
title Persistent delusional disorder: psychopathological remission associated with clozapine-induced epileptic seizures
title_full Persistent delusional disorder: psychopathological remission associated with clozapine-induced epileptic seizures
title_fullStr Persistent delusional disorder: psychopathological remission associated with clozapine-induced epileptic seizures
title_full_unstemmed Persistent delusional disorder: psychopathological remission associated with clozapine-induced epileptic seizures
title_short Persistent delusional disorder: psychopathological remission associated with clozapine-induced epileptic seizures
title_sort persistent delusional disorder: psychopathological remission associated with clozapine-induced epileptic seizures
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479170/
http://dx.doi.org/10.1192/j.eurpsy.2023.2286
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