Cargando…
Acute-on-Chronic Liver Failure and Successful Liver Transplantation in Pyruvate Kinase Deficiency
Liver transplant is a rare phenomenon for pyruvate kinase deficiency (PKD)-related liver disease and can be mediated by multiple mechanisms. In this report, we present a 55-year-old man with PKD who had acute-on-chronic liver failure with kidney failure and marked hyperbilirubinemia. His liver disea...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479345/ https://www.ncbi.nlm.nih.gov/pubmed/37674879 http://dx.doi.org/10.14309/crj.0000000000001143 |
_version_ | 1785101561039421440 |
---|---|
author | Elkin, Baila Allende, Daniela S. Sengupta, Shreya |
author_facet | Elkin, Baila Allende, Daniela S. Sengupta, Shreya |
author_sort | Elkin, Baila |
collection | PubMed |
description | Liver transplant is a rare phenomenon for pyruvate kinase deficiency (PKD)-related liver disease and can be mediated by multiple mechanisms. In this report, we present a 55-year-old man with PKD who had acute-on-chronic liver failure with kidney failure and marked hyperbilirubinemia. His liver disease was from recurrent cholangitis, cholestasis from hemolysis, and iron deposition (likely from both repeated transfusions in youth and chronic hemolysis), all consequences of his PKD. He received a liver transplant and had a good outcome. Our case highlights the mechanisms of liver injury in PKD and successful transplantation for this rare complication. |
format | Online Article Text |
id | pubmed-10479345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer |
record_format | MEDLINE/PubMed |
spelling | pubmed-104793452023-09-06 Acute-on-Chronic Liver Failure and Successful Liver Transplantation in Pyruvate Kinase Deficiency Elkin, Baila Allende, Daniela S. Sengupta, Shreya ACG Case Rep J Case Report Liver transplant is a rare phenomenon for pyruvate kinase deficiency (PKD)-related liver disease and can be mediated by multiple mechanisms. In this report, we present a 55-year-old man with PKD who had acute-on-chronic liver failure with kidney failure and marked hyperbilirubinemia. His liver disease was from recurrent cholangitis, cholestasis from hemolysis, and iron deposition (likely from both repeated transfusions in youth and chronic hemolysis), all consequences of his PKD. He received a liver transplant and had a good outcome. Our case highlights the mechanisms of liver injury in PKD and successful transplantation for this rare complication. Wolters Kluwer 2023-09-05 /pmc/articles/PMC10479345/ /pubmed/37674879 http://dx.doi.org/10.14309/crj.0000000000001143 Text en © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Case Report Elkin, Baila Allende, Daniela S. Sengupta, Shreya Acute-on-Chronic Liver Failure and Successful Liver Transplantation in Pyruvate Kinase Deficiency |
title | Acute-on-Chronic Liver Failure and Successful Liver Transplantation in Pyruvate Kinase Deficiency |
title_full | Acute-on-Chronic Liver Failure and Successful Liver Transplantation in Pyruvate Kinase Deficiency |
title_fullStr | Acute-on-Chronic Liver Failure and Successful Liver Transplantation in Pyruvate Kinase Deficiency |
title_full_unstemmed | Acute-on-Chronic Liver Failure and Successful Liver Transplantation in Pyruvate Kinase Deficiency |
title_short | Acute-on-Chronic Liver Failure and Successful Liver Transplantation in Pyruvate Kinase Deficiency |
title_sort | acute-on-chronic liver failure and successful liver transplantation in pyruvate kinase deficiency |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479345/ https://www.ncbi.nlm.nih.gov/pubmed/37674879 http://dx.doi.org/10.14309/crj.0000000000001143 |
work_keys_str_mv | AT elkinbaila acuteonchronicliverfailureandsuccessfullivertransplantationinpyruvatekinasedeficiency AT allendedanielas acuteonchronicliverfailureandsuccessfullivertransplantationinpyruvatekinasedeficiency AT senguptashreya acuteonchronicliverfailureandsuccessfullivertransplantationinpyruvatekinasedeficiency |