Lenvatinib-Induced Tumor Lysis Syndrome in Advanced Hepatocellular Carcinoma

This case report describes a 48-year-old man with hepatocellular carcinoma who developed tumor lysis syndrome (TLS) after 7 days of starting lenvatinib therapy. The patient was hospitalized and received appropriate interventions, including aggressive hydration, allopurinol, rasburicase, and electrol...

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Autores principales: Goyal, Manjeet Kumar, Singh, Arshdeep, Kumar Gupta, Yogesh, Kaur Dhaliwal, Kanwarpal, Sood, Ajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479354/
https://www.ncbi.nlm.nih.gov/pubmed/37674881
http://dx.doi.org/10.14309/crj.0000000000001139
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author Goyal, Manjeet Kumar
Singh, Arshdeep
Kumar Gupta, Yogesh
Kaur Dhaliwal, Kanwarpal
Sood, Ajit
author_facet Goyal, Manjeet Kumar
Singh, Arshdeep
Kumar Gupta, Yogesh
Kaur Dhaliwal, Kanwarpal
Sood, Ajit
author_sort Goyal, Manjeet Kumar
collection PubMed
description This case report describes a 48-year-old man with hepatocellular carcinoma who developed tumor lysis syndrome (TLS) after 7 days of starting lenvatinib therapy. The patient was hospitalized and received appropriate interventions, including aggressive hydration, allopurinol, rasburicase, and electrolyte management. The patient's condition improved, and he was eventually discharged from the hospital. This case highlights the potential risk of TLS in patients with hepatocellular carcinoma receiving lenvatinib therapy, even after a short duration, and emphasizes the importance of early recognition and management of TLS to prevent serious complications.
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spelling pubmed-104793542023-09-06 Lenvatinib-Induced Tumor Lysis Syndrome in Advanced Hepatocellular Carcinoma Goyal, Manjeet Kumar Singh, Arshdeep Kumar Gupta, Yogesh Kaur Dhaliwal, Kanwarpal Sood, Ajit ACG Case Rep J Case Report This case report describes a 48-year-old man with hepatocellular carcinoma who developed tumor lysis syndrome (TLS) after 7 days of starting lenvatinib therapy. The patient was hospitalized and received appropriate interventions, including aggressive hydration, allopurinol, rasburicase, and electrolyte management. The patient's condition improved, and he was eventually discharged from the hospital. This case highlights the potential risk of TLS in patients with hepatocellular carcinoma receiving lenvatinib therapy, even after a short duration, and emphasizes the importance of early recognition and management of TLS to prevent serious complications. Wolters Kluwer 2023-09-05 /pmc/articles/PMC10479354/ /pubmed/37674881 http://dx.doi.org/10.14309/crj.0000000000001139 Text en © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Goyal, Manjeet Kumar
Singh, Arshdeep
Kumar Gupta, Yogesh
Kaur Dhaliwal, Kanwarpal
Sood, Ajit
Lenvatinib-Induced Tumor Lysis Syndrome in Advanced Hepatocellular Carcinoma
title Lenvatinib-Induced Tumor Lysis Syndrome in Advanced Hepatocellular Carcinoma
title_full Lenvatinib-Induced Tumor Lysis Syndrome in Advanced Hepatocellular Carcinoma
title_fullStr Lenvatinib-Induced Tumor Lysis Syndrome in Advanced Hepatocellular Carcinoma
title_full_unstemmed Lenvatinib-Induced Tumor Lysis Syndrome in Advanced Hepatocellular Carcinoma
title_short Lenvatinib-Induced Tumor Lysis Syndrome in Advanced Hepatocellular Carcinoma
title_sort lenvatinib-induced tumor lysis syndrome in advanced hepatocellular carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10479354/
https://www.ncbi.nlm.nih.gov/pubmed/37674881
http://dx.doi.org/10.14309/crj.0000000000001139
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